Department of Nutrition and Dietetics, Auburn University, Auburn, AL, USA.
School of Kinesiology, Auburn University, Auburn, AL, USA.
Physiol Rep. 2021 Mar;9(5):e14773. doi: 10.14814/phy2.14773.
Fetuin-A (Fet-A), secreted by the liver and adipose tissue, inhibits insulin receptor tyrosine kinase activity and modulates insulin action. Numerous studies have shown association of elevated serum Fet-A concentrations with obesity, non-alcoholic fatty liver disease, and type 2 diabetes. Both moderate body weight loss (5%-10%) and significant body weight loss have been shown to decrease serum Fet-A and improve insulin sensitivity. Currently, there are no studies examining the effects of a single bout of exercise on serum Fet-A or Ser312-pFet-A (pFet-A) responses. We hypothesized that a single bout of moderate-intensity exercise will lower serum Fet-A and that these changes will be associated with an improvement in insulin sensitivity. Thirty-one individuals with obesity and 11 individuals with normal body weight were recruited. Participants underwent a single bout of treadmill walking, expending 500 kcal at 60%-70% VO . Oral glucose tolerance tests (OGTT) were administered before the single bout of exercise (Pre Ex) and 24 h after exercise (24h Post Ex). In individuals with obesity, we observed a transient elevation of serum Fet-A concentrations, but not pFet-A, immediately after exercise (Post Ex). Further, a single bout of exercise decreased glucose , insulin , and insulin resistance index in individuals with obesity. Consistent with this improvement in insulin sensitivity, we observed that Fet-A , pFet-A , 2 h pFet-A, and 2 h pFet-A/Fet-A were significantly lower following a single bout of exercise. Further, reductions in serum Fet-A 24h Post Ex were correlated with a reduction in insulin resistance index. Together, this suggests that alterations in serum Fet-A following a single bout of moderate-intensity endurance exercise may play a role in the improvement of insulin sensitivity. CLINICAL TRIAL REGISTRATION: NCT03478046; https://clinicaltrials.gov/ct2/show/NCT03478046.
胎球蛋白 A（Fet-A）由肝脏和脂肪组织分泌，可抑制胰岛素受体酪氨酸激酶活性并调节胰岛素作用。大量研究表明，血清 Fet-A 浓度升高与肥胖、非酒精性脂肪肝和 2 型糖尿病有关。适度的体重减轻（5%-10%）和显著的体重减轻都已被证明可以降低血清 Fet-A 并改善胰岛素敏感性。目前，还没有研究检查单次运动对血清 Fet-A 或 Ser312-pFet-A（pFet-A）反应的影响。我们假设单次中等强度运动将降低血清 Fet-A，并且这些变化将与胰岛素敏感性的改善相关。招募了 31 名肥胖者和 11 名体重正常者。参与者进行了一次跑步机步行，在 60%-70%VO 下消耗 500 卡路里。在单次运动前（Pre Ex）和运动后 24 小时（24h Post Ex）进行口服葡萄糖耐量试验（OGTT）。在肥胖者中，我们观察到运动后立即（Post Ex）血清 Fet-A 浓度短暂升高，但 pFet-A 没有升高。此外，单次运动可降低肥胖者的血糖、胰岛素和胰岛素抵抗指数。与胰岛素敏感性的改善一致，我们观察到单次运动后 Fet-A、pFet-A、2 小时 pFet-A 和 2 小时 pFet-A/Fet-A 均显著降低。此外，运动后 24 小时血清 Fet-A 的降低与胰岛素抵抗指数的降低相关。总之，这表明单次中等强度耐力运动后血清 Fet-A 的变化可能在胰岛素敏感性的改善中起作用。临床试验注册：NCT03478046；https://clinicaltrials.gov/ct2/show/NCT03478046。
