Lebedev M A, Wise S P
Laboratory of Systems Neuroscience, National Institute of Mental Health, 49 Convent Drive, Bldg. 49, Room B1EE17, MSC 4401, Bethesda MD 20892-4401, USA.
Eur J Neurosci. 2001 Mar;13(5):1002-8. doi: 10.1046/j.0953-816x.2001.01457.x.
We tested whether neuronal activity in the dorsal premotor cortex (PMd) reflected the orientation of selective spatial attention, as opposed to the target of a reaching movement, eye position and saccade direction. These four spatial variables were dissociated in two tasks, which both required that a monkey attend to a robot's location in order to know when to make a movement. However, the target of the reaching movement varied; it was the robot's location in one task, but a different location in the other task. Eye position was recorded, but not explicitly controlled. Of 199 PMd neurons sampled, 19% had activity related to eye position, and an overlapping 11% were related to saccade direction (totaling 24% of the PMd sample). Of the 152 PMd neurons that lacked oculomotor relationships, approximately 20% reflected the orientation of selective spatial attention. Attentional tuning may account, at least in part, for gaze-independent receptive fields and visuospatial, target or goal relationships in tasks involving stimulus-response incompatibility.
我们测试了背侧运动前皮层（PMd）中的神经元活动是否反映了选择性空间注意的方向，而非伸手动作的目标、眼睛位置和扫视方向。这四个空间变量在两项任务中被区分开来，这两项任务都要求猴子关注机器人的位置，以便知道何时做出动作。然而，伸手动作的目标有所不同；在一项任务中是机器人的位置，而在另一项任务中是不同的位置。记录了眼睛位置，但未进行明确控制。在采样的199个PMd神经元中，19%的神经元活动与眼睛位置有关，重叠的11%与扫视方向有关（占PMd样本的24%）。在152个与眼球运动无关的PMd神经元中，约20%反映了选择性空间注意的方向。在涉及刺激-反应不相容性任务中，注意调谐可能至少部分地解释了与注视无关的感受野以及视觉空间、目标或目的关系。
