Feenstra M G, Vogel M, Botterblom M H, Joosten R N, de Bruin J P
Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam ZO, The Netherlands.
Eur J Neurosci. 2001 Mar;13(5):1051-4. doi: 10.1046/j.0953-816x.2001.01471.x.
We used bilateral microdialysis in the medial prefrontal cortex (PFC) of awake, freely moving rats to study aversive conditioning to an auditory cue in the controlled environment of the Skinner box. The presentation of the explicit conditioned stimuli (CS), previously associated with foot shocks, caused increased dopamine (DA) and noradrenaline (NA) efflux. This conditioned response was dependent on the immediate pairing of the two stimuli; in the pseudoconditioned group that received an equal number of both stimuli, but in an unpaired fashion, no conditioned increases in efflux were observed.
我们在清醒、自由活动的大鼠内侧前额叶皮质（PFC）中使用双侧微透析技术，以研究在斯金纳箱的可控环境中对听觉线索的厌恶条件反射。先前与足部电击相关的明确条件刺激（CS）的呈现，导致多巴胺（DA）和去甲肾上腺素（NA）外流增加。这种条件反应依赖于两种刺激的即时配对；在接受相同数量的两种刺激但以非配对方式呈现的假条件反射组中，未观察到外流的条件性增加。
