通过使用裂解流感疫苗免疫雪貂来预防流感。
The protection of ferrets against influenza by immunization with a split influenza vaccine.
作者信息
Brady M I, Furminger I G
出版信息
Dev Biol Stand. 1975;28:167-72.
PMID:1126566
Abstract
Ferrets were vaccinated with either A/England/42/72 zonal purified influenza queous vaccine containing whole virus particles, or a subunit vaccine containing the purified hemagglutinin and neura-minidase proteins of A/England/42/72 adsorbed onto aluminium hydroxide. The immune status of the ferrets was assessed by reaction to challenge with virulent live virus of the homologous strain. In the preliminary experiment reported, the subunit vaccine conferred greater protection than the zonal purified vaccine.
摘要
雪貂分别接种了含全病毒颗粒的A/英格兰/42/72区域纯化流感水性疫苗，或含吸附于氢氧化铝上的A/英格兰/42/72纯化血凝素和神经氨酸酶蛋白的亚单位疫苗。通过对同源毒株强毒活病毒攻击的反应来评估雪貂的免疫状态。在报告的初步实验中，亚单位疫苗比区域纯化疫苗提供了更好的保护。
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