神经氨酸酶对小鼠体内灭活流感病毒疫苗效力的影响。
Effect of neuraminidase on potency of inactivated influenza virus vaccines in mice.
作者信息
Reichert E, Mauler R
出版信息
Dev Biol Stand. 1975;28:319-23.
The protective effect of neuraminidase was studied in a mouse protection test using isolated neuraminidase of A2/Aichi/68(H3N2) virus and the complete recombinant virus A/eq(Heq-1)-HK(N2) as antigens. Immunized mice were protected against A2/Aichi(H3N2) challenge virus; however, the protection rate was low in comparison to animals immunized with comparable amounts of the complete A2/68(H3N2) virus9 Furthermore there was no cross-protection against A2/Asia/57(H2N2) challenge virus. The protective effect of neuraminidase was not impaired by Tween-ether treatment of the A/eq(Heq-1)-HK(N2) recombinant virus.
在一项小鼠保护试验中，以A2/爱知/68（H3N2）病毒的分离神经氨酸酶和完整的重组病毒A/eq（Heq-1）-HK（N2）作为抗原，研究了神经氨酸酶的保护作用。免疫小鼠对A2/爱知（H3N2）攻击病毒具有抵抗力；然而，与用等量完整的A2/68（H3N2）病毒免疫的动物相比，保护率较低。此外，对A2/亚洲/57（H2N2）攻击病毒没有交叉保护作用。用吐温-乙醚处理A/eq（Heq-1）-HK（N2）重组病毒不会损害神经氨酸酶的保护作用。
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