抗神经氨酸酶抗体在流感病毒感染免疫中的作用。
The role of antineuraminidase antibody in immunity to influenza virus infection.
作者信息
Schulman J L
出版信息
Bull World Health Organ. 1969;41(3):647-50.
Abstract
Experimental studies in mice have provided evidence that antibody specific for viral neuraminidase markedly inhibits influenza virus replication in the lungs of animals challenged with virus containing homologous neuraminidase. In contrast to antihaemagglutinin antibody, antineuraminidase antibody does not increase resistance to the initiation of infection, but does reduce the capacity for subsequent transmission of infection.The 1968 Hong Kong virus was found to possess a haemagglutinin antigen markedly different from previous A2 strains but its neuraminidase is indistinguishable from the enzyme antigens of 1967-68 A2 viruses, and protection of mice immunized with 1957 and 1967 A2 viruse and challenged with Hong Kong virus was entirely attributable to antineuraminidase antibody.The desirability of systematically examining the protective effects of antineuraminidase antibody in man and of revising current methods for selection and standardization of influenza vaccines are discussed.
摘要
对小鼠的实验研究已提供证据表明，针对病毒神经氨酸酶的特异性抗体可显著抑制在受到含同源神经氨酸酶的病毒攻击的动物肺部中的流感病毒复制。与抗血凝素抗体不同，抗神经氨酸酶抗体不会增加对感染起始的抵抗力，但会降低后续感染传播的能力。1968年香港病毒被发现具有一种与先前A2毒株明显不同的血凝素抗原，但其神经氨酸酶与1967 - 1968年A2病毒的酶抗原无法区分，用1957年和1967年A2病毒免疫并受到香港病毒攻击的小鼠的保护完全归因于抗神经氨酸酶抗体。本文讨论了系统研究抗神经氨酸酶抗体在人体中的保护作用以及修订当前流感疫苗选择和标准化方法的必要性。
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