Covey M, Sweeney D F, Terry R, Sankaridurg P R, Holden B A
The Cornea and Contact Lens Research Unit, School of Optometry and The Cooperative Research Centrefor Eye Research and Technology, University of New South Wales, Sydney, Australia.
Optom Vis Sci. 2001 Feb;78(2):95-9. doi: 10.1097/00006324-200102000-00009.
To determine whether the eyes of high-Dk soft contact lens wearing subjects can be discriminated from non-contact lens wearing subjects.
This study was a prospective masked assessment of 32 subjects, 16 of whom wore experimental high-Dk soft contact lenses and 16 of whom did not wear contact lenses. Subjects wore high-Dk lenses on a 30-night replacement schedule for an average of 9 months. Tear film characteristics, staining and vascularization of the cornea, conjunctival staining, and the presence of microcysts in the corneal epithelium were assessed using slitlamp microscopy. The endothelium was examined for polymegethism.
No differences were found between the two groups in any of the variables that were examined (p > 0.05) except that the high-Dk lens wearing group had about twofold more tear film debris and 2.5-fold more severe conjunctival staining (p < 0.05).
Hypoxia-associated effects were not apparent in the eyes of subjects wearing experimental high-Dk soft contact lenses. Conjunctival staining can generally distinguish lens wearers from non-lens wearers and can be used to discriminate between high-Dk lens wearing subjects and non-lens wearing subjects.
确定佩戴高透氧性软性隐形眼镜的受试者的眼睛是否能与未佩戴隐形眼镜的受试者区分开来。
本研究是对32名受试者进行的前瞻性盲法评估，其中16人佩戴实验性高透氧性软性隐形眼镜，16人未佩戴隐形眼镜。受试者按照30晚更换一次的时间表佩戴高透氧性镜片，平均佩戴9个月。使用裂隙灯显微镜评估泪膜特征、角膜染色和血管化、结膜染色以及角膜上皮中微囊肿的存在情况。检查内皮细胞是否存在大小不均一性。
在检查的任何变量中，两组之间均未发现差异（p>0.05），但佩戴高透氧性镜片组的泪膜碎片约多两倍，结膜染色严重程度高2.5倍（p<0.05）。
在佩戴实验性高透氧性软性隐形眼镜的受试者眼中，缺氧相关影响并不明显。结膜染色通常可区分佩戴隐形眼镜者与未佩戴隐形眼镜者，并可用于区分佩戴高透氧性镜片的受试者与未佩戴镜片的受试者。
