Valdezate S, Vindel A, Maiz L, Baquero F, Escobar H, Cantón R
Hospital Ramón y Cajal, Madrid, Spain.
Emerg Infect Dis. 2001 Jan-Feb;7(1):113-22. doi: 10.3201/eid0701.010116.
During 1991 to 1998 at least one Stenotrophomonas maltophilia pulmonary infection was observed in 25 (24%) of 104 cystic fibrosis patients at the same unit of our hospital in Spain. Ribotyping and pulse-field gel electrophoresis (PFGE) characterization of 76 S. maltophilia isolates from these patients indicated an overall clonal incidence of 47.1%, reflecting new strains in 44% of patients with repeated positive cultures for S. maltophilia. Six patients with repeated episodes were persistently colonized (> or = 6 months) with the same strain. S. maltophilia bacterial counts were higher (geometric mean, 2.9 x 10(8) cfu/mL) in patients with repeated episodes than in those with a single episode (8.4 x 10(4) cfu/mL, p < 0.01). Single episodes of S. maltophilia occurred in patients < 10 years of age (43% [6/14]), whereas chronic colonization occurred more frequently in older patients (> 16 years of age).
1991年至1998年期间,在西班牙我院同一科室的104例囊性纤维化患者中,有25例(24%)至少观察到一次嗜麦芽窄食单胞菌肺部感染。对这些患者的76株嗜麦芽窄食单胞菌分离株进行核糖体分型和脉冲场凝胶电泳(PFGE)分析,结果显示总体克隆发生率为47.1%,这表明在44%嗜麦芽窄食单胞菌培养反复呈阳性的患者中出现了新菌株。6例反复发病的患者被同一菌株持续定植(≥6个月)。反复发病患者的嗜麦芽窄食单胞菌细菌计数(几何平均数为2.9×10⁸cfu/mL)高于单次发病患者(8.4×10⁴cfu/mL,p<0.01)。嗜麦芽窄食单胞菌单次发病多见于10岁以下患者(43%[6/14]),而慢性定植在老年患者(>16岁)中更为常见。