嗜麦芽窄食单胞菌在囊性纤维化患者中的持续性和变异性，马德里，1991 - 1998年
Persistence and variability of Stenotrophomonas maltophilia in cystic fibrosis patients, Madrid, 1991-1998.
作者信息
Valdezate S, Vindel A, Maiz L, Baquero F, Escobar H, Cantón R
机构信息
Hospital Ramón y Cajal, Madrid, Spain.
出版信息
Emerg Infect Dis. 2001 Jan-Feb;7(1):113-22. doi: 10.3201/eid0701.010116.
Abstract
During 1991 to 1998 at least one Stenotrophomonas maltophilia pulmonary infection was observed in 25 (24%) of 104 cystic fibrosis patients at the same unit of our hospital in Spain. Ribotyping and pulse-field gel electrophoresis (PFGE) characterization of 76 S. maltophilia isolates from these patients indicated an overall clonal incidence of 47.1%, reflecting new strains in 44% of patients with repeated positive cultures for S. maltophilia. Six patients with repeated episodes were persistently colonized (> or = 6 months) with the same strain. S. maltophilia bacterial counts were higher (geometric mean, 2.9 x 10(8) cfu/mL) in patients with repeated episodes than in those with a single episode (8.4 x 10(4) cfu/mL, p < 0.01). Single episodes of S. maltophilia occurred in patients < 10 years of age (43% [6/14]), whereas chronic colonization occurred more frequently in older patients (> 16 years of age).
摘要
1991年至1998年期间，在西班牙我院同一科室的104例囊性纤维化患者中，有25例（24%）至少观察到一次嗜麦芽窄食单胞菌肺部感染。对这些患者的76株嗜麦芽窄食单胞菌分离株进行核糖体分型和脉冲场凝胶电泳（PFGE）分析，结果显示总体克隆发生率为47.1%，这表明在44%嗜麦芽窄食单胞菌培养反复呈阳性的患者中出现了新菌株。6例反复发病的患者被同一菌株持续定植（≥6个月）。反复发病患者的嗜麦芽窄食单胞菌细菌计数（几何平均数为2.9×10⁸cfu/mL）高于单次发病患者（8.4×10⁴cfu/mL，p<0.01）。嗜麦芽窄食单胞菌单次发病多见于10岁以下患者（43%[6/14]），而慢性定植在老年患者（>16岁）中更为常见。
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1
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2
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J Clin Microbiol. 1999 Nov;37(11):3594-600. doi: 10.1128/JCM.37.11.3594-3600.1999.
3
Two consecutive outbreaks of Stenotrophomonas maltophilia (Xanthomonas maltophilia) in an intensive-care unit defined by restriction fragment-length polymorphism typing.通过限制性片段长度多态性分型确定的重症监护病房中嗜麦芽窄食单胞菌（嗜麦芽黄单胞菌）的两次连续暴发。
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9
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