Ishih A, Ikeya C, Yanoh M, Takezoe H, Miyase T, Terada M
Department of Parasitology, Hamamatsu University School of Medicine, 3600 Handa-cho, 431-3192, Hamamatsu, Japan.
Parasitol Int. 2001 Mar;50(1):33-9. doi: 10.1016/s1383-5769(00)00069-6.
The antimalarial activity of the hot-water extract of Hydrangea macrophylla var. Otaksa leaves was evaluated against Plasmodium yoelii 17XL in mice. Non-treated control mice died from 6 to 7 days after infection, but mice treated with the leaf extract survived during the experiment. Mice given the extract orally showed low parasitemia levels during administration. Following a transient recrudescence of malaria parasites in the bloodstream of treated mice, no parasites could be detected by a microscopic examination. Furthermore, the 30% MeOH aq. eluate and 50% MeOH aq. eluate from dried leaves of H. macrophylla var. Otaksa showed an antimalarial activity in vivo. Sulfamonomethoxine was orally given to infected mice to compare with the antimalarial activity of the hot-water extract of leaves. Sulfamonomethoxine given orally reduced parasitemia, but no complete cure of mice was observed.
对紫阳花叶热水提取物针对小鼠约氏疟原虫17XL的抗疟活性进行了评估。未处理的对照小鼠在感染后6至7天死亡，但用叶提取物处理的小鼠在实验期间存活。口服提取物的小鼠在给药期间显示出低寄生虫血症水平。在处理过的小鼠血液中疟原虫短暂复发后，显微镜检查未检测到寄生虫。此外，大叶绣球变种尾崎干叶的30%甲醇水溶液洗脱物和50%甲醇水溶液洗脱物在体内显示出抗疟活性。将磺胺间甲氧嘧啶口服给予感染小鼠以与叶热水提取物的抗疟活性进行比较。口服磺胺间甲氧嘧啶可降低寄生虫血症，但未观察到小鼠完全治愈。
