An Asymmetric Enzyme-Catalyzed Retro-Claisen Reaction for the Desymmetrization of Cyclic beta-Diketones This work was supported by the BBSRC (grants to N.J.T. and S.L.F.) and the European Commission (grant to J.G.). We also thank Mr. J. Millar and Dr. D. Uhrin for assistance with NMR spectroscopy.

作者信息

Grogan Gideon, Graf Jürgen, Jones Aileen, Parsons Simon, Turner Nicholas J., Flitsch Sabine L.

机构信息

Edinburgh Centre for Protein Technology Department of Chemistry, University of Edinburgh The King's Buildings, West Mains Road, Edinburgh EH9 3JJ (UK).

出版信息

Angew Chem Int Ed Engl. 2001 Mar 16;40(6):1111-1114.

PMID:11268092

Abstract

摘要

相似文献

An Asymmetric Enzyme-Catalyzed Retro-Claisen Reaction for the Desymmetrization of Cyclic beta-Diketones This work was supported by the BBSRC (grants to N.J.T. and S.L.F.) and the European Commission (grant to J.G.). We also thank Mr. J. Millar and Dr. D. Uhrin for assistance with NMR spectroscopy.

Angew Chem Int Ed Engl. 2001 Mar 16;40(6):1111-1114.

Merging of Hard Spheres by Phototriggered Micromanipulation K.T. thanks the Mitsubishi Paper Mills Co. T.G., J.H., and L.L. thank the European Commission for a TMR fellowship within the frame of the Marie Curie program, the FWO, and the Flemish Ministry of Education, respectively. J.W.W. and A.S. acknowledge grants from the EU (BICEPS project) and the Royal Dutch Foundation of Science, respectively. This work was further supported by DWTC (Belgium), and ESF through SMARTON. An unrestricted research grant from DSM Research is highly appreciated.

Angew Chem Int Ed Engl. 2001 May 4;40(9):1710-1714.

Origin and True Nature of the Starter Unit for the Rapamycin Polyketide Synthase We thank Dr. Bradley S. Moore for help with the deuterium NMR experiments. This work was supported by grants from The Wellcome Trust (to J.S. and P.F.L.) and from the NIH (AI20264 to H.G.F.).雷帕霉素聚酮合酶起始单元的起源与真实性质我们感谢布拉德利·S·摩尔博士在氘核磁共振实验方面提供的帮助。这项工作得到了惠康信托基金会（资助J.S.和P.F.L.）以及美国国立卫生研究院（资助H.G.F.，项目编号AI20264）的资助。

Angew Chem Int Ed Engl. 2001 Feb 16;40(4):777-779.

Solvent-Free, Low-Temperature, Selective Hydrogenation of Polyenes using a Bimetallic Nanoparticle Ru-Sn Catalyst We thank Dr. R. G. Bell for assistance with the computer graphics, Drs. P. A. Midgeley, V. Keast, and M. Weyland for help with STEM, and gratefully acknowledge the support (via a rolling grant to J.M.T. and an award to B.F.G.J.) of EPSRC and the award of a research fellowship (for G.S.) from the Leverhulme Foundation and a Marie Curie Fellowship within the TMR Programme of the European Commission (for S.H.).使用双金属纳米颗粒Ru-Sn催化剂对多烯进行无溶剂、低温选择性氢化我们感谢R.G. Bell博士在计算机图形方面提供的帮助，感谢P.A. Midgeley博士、V. Keast博士和M. Weyland博士在扫描透射电子显微镜方面提供的帮助，并衷心感谢工程和物理科学研究委员会的支持（通过向J.M.T.提供的滚动资助以及向B.F.G.J.颁发的奖项），以及Leverhulme基金会授予的研究奖学金（给G.S.）和欧盟委员会TMR计划内的玛丽·居里奖学金（给S.H.）。

Angew Chem Int Ed Engl. 2001 Apr 1;40(7):1211-1215.

Resolution and Kinetic Stability of a Chiral Supramolecular Assembly Made of Labile Components Coordination Number Incommensurate Cluster Formation, Part 18. Financial support of this work was provided by NSF CHE-9709621 and by NSF and NATO-NSF exchange grants INT-9603212 and SRG 951516, respectively. We thank the Alexander-von-Humboldt Foundation for a Fellowship to A.T., and a Humboldt Research Award for Senior U.S. Scientists to K.R., and the Miller Foundation for a fellowship to M.Z. The authors gratefully acknowledge the assistance of Dr. F. J. Hollander and Dr. D. L. Caulder in selecting and mounting a suitable single crystal, and Prof. Julie A. Leary, Dr. Ulla N. Andersen, and J. J. Miranda for measuring mass spectra. Part 17: M. Ziegler, J. J. Miranda, U. N. Andersen, D. W. Johnson, J. A. Leary, K. N. Raymond, Angew. Chem., in press.由不稳定组分构成的手性超分子组装体的分辨率和动力学稳定性：配位数不匹配的簇形成，第18部分。本研究得到了美国国家科学基金会（NSF）CHE - 9709621项目以及NSF和北约 - NSF交流基金INT - 9603212和SRG 951516的资助。我们感谢亚历山大·冯·洪堡基金会授予A.T.的奖学金、授予K.R.的洪堡资深美国科学家研究奖，以及米勒基金会授予M.Z.的奖学金。作者们衷心感谢F. J. 霍兰德博士和D. L. 考尔德博士在挑选和安装合适单晶方面提供的帮助，以及朱莉·A. 利里教授、乌拉·N. 安德森博士和J. J. 米兰达在测量质谱方面提供的帮助。第17部分：M. 齐格勒、J. J. 米兰达、U. N. 安德森、D. W. 约翰逊、J. A. 利里、K. N. 雷蒙德，《德国应用化学》，即将发表。

Angew Chem Int Ed Engl. 2001 Jan 5;40(1):157-160.

Novel IBX-Mediated Processes for the Synthesis of Amino Sugars and Libraries Thereof We thank Dr. D. H. Huang, Dr. G. Siuzdak, and Dr. R. Chadha for NMR spectroscopic, mass spectrometric, and X-ray crystallographic assistance, respectively, and Prof. H. M. R. Hoffmann and Prof. A. Eschenmoser for helpful discussions. We also thank Dr. Maria-Rosa Rodriguez and Mr. Keith Wilcoxen of these laboratories for early intermediates leading to 9-12. This work was financially supported by the National Institutes of Health (USA), The Skaggs Institute for Chemical Biology, fellowships from the Ministerio de Educacion y Cultura, Spain (J.A.V.) and the National Science Foundation (P.S.B), and grants from Array Biopharma, Pfizer, GlaxoWellcome, Merck, Schering Plough, Hoffmann-LaRoche, Boehringer Ingelheim, DuPont, and Abbott Laboratories.用于合成氨基糖及其文库的新型IBX介导方法我们分别感谢D. H. Huang博士、G. Siuzdak博士和R. Chadha博士在核磁共振光谱、质谱和X射线晶体学方面提供的帮助，以及H. M. R. Hoffmann教授和A. Eschenmoser教授进行的有益讨论。我们还感谢这些实验室的Maria-Rosa Rodriguez博士和Keith Wilcoxen先生提供了通往9-12的早期中间体。这项工作得到了美国国立卫生研究院、斯卡格斯化学生物学研究所、西班牙教育和文化部（J.A.V.）和美国国家科学基金会（P.S.B）的资助，以及Array Biopharma、辉瑞、葛兰素威康、默克、先灵葆雅、霍夫曼-罗氏、勃林格殷格翰、杜邦和雅培实验室的拨款。

Angew Chem Int Ed Engl. 2000 Jul 17;39(14):2525-2529.

The Synthesis of CP-263,114 and CP-225,917: Striking Long-Range Stereocontrol in the Fashioning of C7 Financial support was provided by the National Institutes of Health (Grant nos. CA-28824 and HL-25848 for S.J.D., CA-08748 for the Sloan-Kettering Institute Core Facility). Q.T. gratefully acknowledges the US Department of Defense for a postdoctoral fellowship (U.S. Army grant no. DAMD-17-99-1-9373). We thank the Pfizer Corporation, particularly Dr. T. Kaneko and Dr. T. T. Dabrah for discussions and for providing valuable CP samples from fermentation broth. We are grateful to Dr. Dongfang Meng for his major contributions to this work. We also thank George Sukenick of the Sloan-Kettering Institute Core Facility for mass spectral analyses and assistance in NMR spectroscopic and HPLC analyses, and Sylvi Rusli for mass spectral analyses.CP - 263,114和CP - 225,917的合成：在构建C7时显著的远程立体控制美国国立卫生研究院提供了资金支持（给S.J.D.的CA - 28824和HL - 25848号拨款，给斯隆 - 凯特琳研究所核心设施的CA - 08748号拨款）。Q.T.衷心感谢美国国防部授予的博士后奖学金（美国陆军拨款号DAMD - 17 - 99 - 1 - 9373）。我们感谢辉瑞公司，特别是T. Kaneko博士和T.T. Dabrah博士进行的讨论以及提供来自发酵液的宝贵CP样品。我们感谢董方孟博士对这项工作的重大贡献。我们还感谢斯隆 - 凯特琳研究所核心设施的George Sukenick进行质谱分析以及在核磁共振光谱分析和高效液相色谱分析方面提供的帮助，感谢Sylvi Rusli进行质谱分析。

Angew Chem Int Ed Engl. 2000 Dec 15;39(24):4509-4511.

Synthesis of a Cyclopropene Analogue of Ceramide, a Potent Inhibitor of Dihydroceramide Desaturase This work was supported by the Dirección General de Enseñanza Superior e Investigación Científica (grant PB97-1171) and the Departament d'Universitats, Recerca i Societat de la Informació, Generalitat de Catalunya (grant 1999-SGR 00187 and a Predoctoral fellowship to G.T.). We thank Dr. J. Casas, Dr. A. Delgado, and Dr. J. Joglar for their help in different aspects of this work.二氢神经酰胺去饱和酶的强效抑制剂——神经酰胺环丙烯类似物的合成本研究得到了西班牙高等教育与科学研究总局（项目编号PB97 - 1171）以及加泰罗尼亚自治区大学、研究与信息社会部（项目编号1999 - SGR 00187，并为G.T.提供了博士前奖学金）的资助。我们感谢J. Casas博士、A. Delgado博士和J. Joglar博士在本研究不同方面给予的帮助。

Angew Chem Int Ed Engl. 2001 May 18;40(10):1960-1962.

Ruthenium-Catalyzed One-Step Transformation of Propargylic Alcohols into Alkylidene Cyclobutenes: X-ray Characterization of an Ru(eta(3)-cyclobutenyl) Intermediate This work was supported by the CNRS and the Ministère de la Recherche. The authors are grateful to the latter for a PhD grant to J. LP. The authors wish to thank the European Cost Program D17/003/00 and the Région Bretagne for financial support. They are also grateful to A. Bondon for helpful assistance in NMR analysis.

Angew Chem Int Ed Engl. 2001 Aug 3;40(15):2912-2915.

Total Synthesis of Apoptolidin: Part 2. Coupling of Key Building Blocks and Completion of the Synthesis We thank Dr. C. Khosla and Dr. Y. Hayakawa for generous gifts of apoptolidin, and Dr. D. H. Huang and Dr. G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. This work was financially supported by the National Institutes of Health (USA), the Skaggs Institute for Chemical Biology, American Biosciences, a predoctoral fellowship from Boehringer Ingelheim (to Y.L.), a postdoctoral fellowship the George Hewitt Foundation (to K.C.F.), and grants from Abbott Laboratories, ArrayBiopharma, Bayer, Boehringer Ingelheim, DuPont, Glaxo, Hoffmann-LaRoche, Merck, Novartis, Pfizer, and Schering Plough.

Angew Chem Int Ed Engl. 2001 Oct 15;40(20):3854-3857.

引用本文的文献

Can we measure catalyst efficiency in asymmetric chemical reactions? A theoretical approach.不对称化学反应中催化剂效率能否衡量？一种理论方法。

Beilstein J Org Chem. 2009 Nov 19;5:67. doi: 10.3762/bjoc.5.67.

Biotransformations of 2-methylisoborneol by camphor-degrading bacteria.樟脑降解细菌对2-甲基异冰片醇的生物转化

Appl Environ Microbiol. 2009 Feb;75(3):583-8. doi: 10.1128/AEM.02126-08. Epub 2008 Dec 5.

Structure of the ThDP-dependent enzyme benzaldehyde lyase refined to 1.65 A resolution.硫胺素二磷酸（ThDP）依赖性酶苯甲醛裂解酶的结构精修至1.65埃分辨率。

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Jul 1;63(Pt 7):546-8. doi: 10.1107/S1744309107028576. Epub 2007 Jun 15.

Emergent mechanistic diversity of enzyme-catalysed beta-diketone cleavage.酶催化β-二酮裂解的新出现的机制多样性

Biochem J. 2005 Jun 15;388(Pt 3):721-30. doi: 10.1042/BJ20042038.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验