Lundstrøm M S, Høgdall C K, Nielsen A L, Nyholm H C
Department of Gynecology and Obstetrics, University of Copenhagen, Hvidovre Hospital, Copenhagen, Denmark.
Anticancer Res. 2000 Sep-Oct;20(5C):3903-6.
CA125 and tetranectin (TN) are prognostic markers in ovarian cancer. This study examines the values of these markers in endometrial cancer.
TN and CA125 were determined preoperatively in 99 patients with primary endometrioid adenocarcinoma and evaluated in relation to tumor grade, stage and cancer survival.
The CA125 levels correlated significantly with tumor stage. Dichotomized according to a cut-off level of 35 U/ml, CA125 significantly correlated with cancer death. Multivariate regression analysis of cancer survival time showed that CA125 > 35 U/ml was not an independent factor when stage was introduced. TN levels were within the normal range in all patients and did not show any association with tumor grade, stage or survival.
The study confirmed the role of CA125 as a prognostic factor in endometrial cancer and may be of aid in pointing out patients at high risk, whereas tetranectin did not show any prognostic effect.
CA125和纤连蛋白（TN）是卵巢癌的预后标志物。本研究探讨这些标志物在子宫内膜癌中的价值。
对99例原发性子宫内膜样腺癌患者术前测定TN和CA125，并根据肿瘤分级、分期和癌症生存率进行评估。
CA125水平与肿瘤分期显著相关。以35 U/ml的临界值进行二分法分析，CA125与癌症死亡显著相关。癌症生存时间的多因素回归分析表明，当引入分期时，CA125>35 U/ml不是一个独立因素。所有患者的TN水平均在正常范围内，且与肿瘤分级、分期或生存率无任何关联。
该研究证实了CA125作为子宫内膜癌预后因素的作用，可能有助于指出高危患者，而纤连蛋白未显示出任何预后作用。
