术前血清CA125水平对子宫内膜癌患者预后预测的价值。

Value of pre-operative serum CA125 level for prediction of prognosis in patients with endometrial cancer.

作者信息

Chen Yu-Li, Huang Chia-Yen, Chien Tsai-Yen, Huang Shih-Hung, Wu Ching-Jung, Ho Chih-Ming

机构信息

Gynecologic Cancer Center, Department of Obstetrics and Gynecology, Cathay General Hospital, Taipei, Taiwan.

出版信息

Aust N Z J Obstet Gynaecol. 2011 Oct;51(5):397-402. doi: 10.1111/j.1479-828X.2011.01325.x. Epub 2011 Jun 9.

DOI:10.1111/j.1479-828X.2011.01325.x

PMID:21806586

Abstract

BACKGROUND

High pre-operative CA125 levels in women with endometrial cancer may be related to lymph node metastases and poor prognosis.

AIM

To evaluate whether pre-operative cancer antigen 125 (CA125) levels are associated with lymph node metastases and prognosis in endometrial cancer.

METHODS

One hundred and twenty women with endometrial cancer were retrospectively reviewed for pre-operative CA125 levels. The results were then correlated with the clinicopathological outcome.

RESULTS

An elevated CA125 (>40 U/mL) was significantly correlated with higher stage, higher grade, increased depth of myometrial invasion, lymph node metastases and the presence of lympho-vascular space involvement in endometrial cancer. Five-year overall survival (OS) and recurrence-free survival (RFS) rates were significantly higher in women with endometrial cancer with CA125 ≤ 40 U/mL than those with CA125 > 40 U/mL (P < 0.001). When women were further stratified according to CA125 levels and lymph node status, OS and RFS were highest for those with CA125 ≤ 40 U/mL and without lymph node metastases, and lowest for those with lymph node metastases and CA125 > 40 U/mL (P < 0.001).

CONCLUSION

The testing of pre-operative CA125 levels may a useful prognostic tool in endometrial cancer management.

摘要

背景

子宫内膜癌女性患者术前CA125水平较高可能与淋巴结转移及预后不良有关。

目的

评估术前癌抗原125（CA125）水平是否与子宫内膜癌的淋巴结转移及预后相关。

方法

回顾性分析120例子宫内膜癌女性患者的术前CA125水平，并将结果与临床病理结果进行关联分析。

结果

CA125升高（>40 U/mL）与子宫内膜癌的更高分期、更高分级、子宫肌层浸润深度增加、淋巴结转移及淋巴血管间隙受累显著相关。CA125≤40 U/mL的子宫内膜癌女性患者的5年总生存率（OS）和无复发生存率（RFS）显著高于CA125>40 U/mL的患者（P<0.001）。当根据CA125水平和淋巴结状态对女性患者进一步分层时，CA125≤40 U/mL且无淋巴结转移的患者的OS和RFS最高，而有淋巴结转移且CA125>40 U/mL的患者的OS和RFS最低（P<0.ooo1）。