Chen Yu-Li, Huang Chia-Yen, Chien Tsai-Yen, Huang Shih-Hung, Wu Ching-Jung, Ho Chih-Ming
Gynecologic Cancer Center, Department of Obstetrics and Gynecology, Cathay General Hospital, Taipei, Taiwan.
Aust N Z J Obstet Gynaecol. 2011 Oct;51(5):397-402. doi: 10.1111/j.1479-828X.2011.01325.x. Epub 2011 Jun 9.
High pre-operative CA125 levels in women with endometrial cancer may be related to lymph node metastases and poor prognosis.
To evaluate whether pre-operative cancer antigen 125 (CA125) levels are associated with lymph node metastases and prognosis in endometrial cancer.
One hundred and twenty women with endometrial cancer were retrospectively reviewed for pre-operative CA125 levels. The results were then correlated with the clinicopathological outcome.
An elevated CA125 (>40 U/mL) was significantly correlated with higher stage, higher grade, increased depth of myometrial invasion, lymph node metastases and the presence of lympho-vascular space involvement in endometrial cancer. Five-year overall survival (OS) and recurrence-free survival (RFS) rates were significantly higher in women with endometrial cancer with CA125 ≤ 40 U/mL than those with CA125 > 40 U/mL (P < 0.001). When women were further stratified according to CA125 levels and lymph node status, OS and RFS were highest for those with CA125 ≤ 40 U/mL and without lymph node metastases, and lowest for those with lymph node metastases and CA125 > 40 U/mL (P < 0.001).
The testing of pre-operative CA125 levels may a useful prognostic tool in endometrial cancer management.
子宫内膜癌女性患者术前CA125水平较高可能与淋巴结转移及预后不良有关。
评估术前癌抗原125（CA125）水平是否与子宫内膜癌的淋巴结转移及预后相关。
回顾性分析120例子宫内膜癌女性患者的术前CA125水平，并将结果与临床病理结果进行关联分析。
CA125升高（>40 U/mL）与子宫内膜癌的更高分期、更高分级、子宫肌层浸润深度增加、淋巴结转移及淋巴血管间隙受累显著相关。CA125≤40 U/mL的子宫内膜癌女性患者的5年总生存率（OS）和无复发生存率（RFS）显著高于CA125>40 U/mL的患者（P<0.001）。当根据CA125水平和淋巴结状态对女性患者进一步分层时，CA125≤40 U/mL且无淋巴结转移的患者的OS和RFS最高，而有淋巴结转移且CA125>40 U/mL的患者的OS和RFS最低（P<0.ooo1）。
术前CA125水平检测可能是子宫内膜癌管理中一种有用的预后工具。
