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[尿培养会改变我们的治疗方法吗?]

[Do urocultures change our therapy approach?].

作者信息

Piñero Acín M J, Martínez Matías M R, Córdoba Gutiérrez M J, Sánchez Rojas T, López Juárez D, Rodríguez Alcalá F J

机构信息

Centro de Salud Sta. M. de Benquerencia, Gerencia de AP de Toledo.

出版信息

Aten Primaria. 2000 Oct 31;26(7):459-63. doi: 10.1016/s0212-6567(00)78703-8.

Abstract

OBJECTIVE

To describe to what extent the results of urocultures modify approaches to therapy and the factors linked to this change.

DESIGN

Cross-sectional, descriptive study by means of review of records.

SETTING

Primary care.

PARTICIPANTS

222 adult urocultures requested at 8 health centres between March and May 1999.

INTERVENTIONS

We extracted from the records age, sex, symptoms, risk factors, and approach to therapy before and after the uroculture. We discarded 358 urocultures because of not finding the clinical record or because the episode or data on the change in approach to therapy was lacking in the record.

RESULTS

The urocultures belonged to patients with a mean age of 54.2, 73.1% of whom were women. 34.7% presented no risk factor for UTI. 44% had no symptoms of UTI. 21.2% of urocultures were positive, with E. coli the most frequently isolated bacteria (69.4%). Empirical antibiotic treatment was called for in 44.6% (70.1% quinolones, 9.3% fosfomycin). After receipt of the result, there was a change of approach in 25 cases (11.4%, SE 2.1%), of whom 15 did not receive empirical treatment (6 with symptoms and 9 without). The antibiotic was changed in 9 of the 99 cases treated empirically (always because of resistance). Among those with change of approach, there was a higher percentage of risk factors (84% against 62%, p < 0.05, chi 2 = 4.47). There were no differences for age, sex, symptoms or bacteria between the two groups.

CONCLUSIONS

There is a quite considerable percentage of urocultures that lead to a change in approach to therapy, although most of the patients had linked risk factors and/or did not receive empirical antibiotic treatment.

摘要

目的

描述尿培养结果在多大程度上改变治疗方法以及与此变化相关的因素。

设计

通过病历回顾进行的横断面描述性研究。

地点

初级保健机构。

参与者

1999年3月至5月期间在8个健康中心要求进行的222例成人尿培养。

干预措施

我们从病历中提取了年龄、性别、症状、危险因素以及尿培养前后的治疗方法。由于未找到临床记录或病历中缺乏关于治疗方法改变的发作或数据,我们舍弃了358例尿培养。

结果

尿培养的患者平均年龄为54.2岁,其中73.1%为女性。34.7%的患者无UTI危险因素。44%的患者无UTI症状。21.2%的尿培养呈阳性,大肠杆菌是最常分离出的细菌(69.4%)。44.6%的患者需要经验性抗生素治疗(70.1%为喹诺酮类,9.3%为磷霉素)。收到结果后,25例患者(11.4%,标准误2.1%)的治疗方法发生了改变,其中15例未接受经验性治疗(6例有症状,9例无症状)。在99例接受经验性治疗的患者中,有9例更换了抗生素(均因耐药)。在治疗方法发生改变的患者中,危险因素的比例更高(84%对62%,p<0.05,卡方=4.47)。两组在年龄、性别、症状或细菌方面无差异。

结论

相当一部分尿培养会导致治疗方法的改变,尽管大多数患者有相关的危险因素和/或未接受经验性抗生素治疗。

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