Janecková R
Endokrinologický ústav, Praha.
Cesk Fysiol. 2001 Feb;50(1):25-30.
The reproductive activity is closely related to the nutritional status of the organism. A new hormone--leptin has been discovered a few years ago, which informs the brain about fat supplies in the body. Leptin participates in the regulation of the reproductive system at both, peripheral and central, levels. There are discussions about leptin as a possible trigger of puberty. The prepubertal leptin levels are low in both sexes; they increase with the onset of puberty. It has been suggested that leptin resistance might exist in the childhood, allowing the onset of the puberty only at the moment, when the adipose stores are adequate for the strongly demanding period of the adolescence. The role of leptin in pathogenesis of polycystic ovary syndrome (PCOS) is studied. The significance of leptin during pregnancy and after birth remains still unclear.
生殖活动与机体的营养状况密切相关。几年前发现了一种新的激素——瘦素，它能向大脑传递体内脂肪供应的信息。瘦素在周围和中枢水平参与生殖系统的调节。关于瘦素是否可能是青春期的触发因素存在一些讨论。青春期前男女的瘦素水平都较低；随着青春期的开始而升高。有人提出，儿童期可能存在瘦素抵抗，只有当脂肪储备足以满足青春期这一需求旺盛时期时，才会开始进入青春期。人们正在研究瘦素在多囊卵巢综合征（PCOS）发病机制中的作用。瘦素在孕期和产后的意义仍不明确。
