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怀孕女性的胎儿性别与瘦素浓度

Fetal sex and leptin concentrations in pregnant females.

作者信息

Al Atawi F, Warsy A, Babay Z, Addar M

机构信息

College of Science, King Saud University.

出版信息

Ann Saudi Med. 2005 Mar-Apr;25(2):124-8. doi: 10.5144/0256-4947.2005.124.

DOI:10.5144/0256-4947.2005.124
PMID:15977690
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6147968/
Abstract

BACKGROUND

Adult females have significantly more leptin than males. We investigated the effect of fetal sex on levels of leptin and other pregnancy hormones (progesterone, estradiol, FSH, LH and beta hCG) in pregnant females during different stages of pregnancy.

PATIENTS AND METHODS

Serum leptin levels in pregnant females followed at King Khaled University Hospital, Riyadh, Saudi Arabia in the year 2001 were estimated at the first, second, and third trimester of pregnancy as well as after delivery. Progesterone, estradiol, FSH, LH and beta hCG levels were also measured.

RESULTS

Leptin levels were significantly higher during all three trimesters in the pregnant females carrying female fetuses compared with those with male fetuses, while other hormones did not differ between the two groups. After delivery, the leptin levels decreased in both groups, and were still higher in the females who delivered baby girls, but the results were not statistically significant.

CONCLUSION

These finding suggests that leptin might play a role in sex regulation during embryonic development.

摘要

背景

成年女性的瘦素水平显著高于男性。我们研究了胎儿性别对怀孕女性在孕期不同阶段瘦素及其他妊娠激素（孕酮、雌二醇、促卵泡激素、促黄体生成素和β-人绒毛膜促性腺激素）水平的影响。

患者与方法

对2001年在沙特阿拉伯利雅得的哈立德国王大学医院接受随访的怀孕女性，在妊娠的第一、第二和第三个月以及分娩后测定血清瘦素水平。同时也测量了孕酮、雌二醇、促卵泡激素、促黄体生成素和β-人绒毛膜促性腺激素水平。

结果

与怀有男性胎儿的怀孕女性相比，怀有女性胎儿的怀孕女性在所有三个孕期的瘦素水平均显著更高，而两组之间的其他激素水平没有差异。分娩后，两组的瘦素水平均下降，分娩女婴的女性瘦素水平仍较高，但结果无统计学意义。

结论

这些发现表明瘦素可能在胚胎发育过程中的性别调节中发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5978/6147968/d0708749d0e8/asm-2-124f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5978/6147968/204c928e6c30/asm-2-124f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5978/6147968/7cd3f23c0e28/asm-2-124f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5978/6147968/3f861a3c2851/asm-2-124f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5978/6147968/d0708749d0e8/asm-2-124f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5978/6147968/204c928e6c30/asm-2-124f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5978/6147968/7cd3f23c0e28/asm-2-124f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5978/6147968/3f861a3c2851/asm-2-124f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5978/6147968/d0708749d0e8/asm-2-124f4.jpg

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