Wang J T, Chang S C, Chen Y C, Luh K T
Department of Internal Medicine, National Taiwan University Hospital, Taipei, ROC.
J Microbiol Immunol Infect. 2000 Dec;33(4):258-62.
Citrobacter freundii was first identified in 1932, since then it has been reported to cause a variety of infections in aged, immunocompromised, and debilitated patients. With the use of broad-spectrum antibiotics, C. freundii has become increasingly resistant to antimicrobial agents. In order to determine the chronological changes in susceptibility and current susceptibility status of C. freundii, we compared the antimicrobial susceptibility of C. freundii in two different time periods, from 1987 to 1988 and from 1997 to 1998. In both time periods, 61 isolates of C. freundii were randomly selected for study from all clinical isolates at National Taiwan University Hospital. The minimum inhibitory concentrations and susceptible rates of 15 antimicrobial agents were compared, and it was found that most C. freundii isolates were resistant to anti-pseudomonal penicillins, first, second, and third generation cephalosporins, gentamicin, tobramycin, and aztreonam. The results indicate that the susceptible rates of C. freundii to aminoglycosides and ciprofloxacin decreased markedly during the period from 1987 to 1998. Cefepime, cefpirome, imipenem, and meropenem remained the most active agents against C. freundii.
弗氏柠檬酸杆菌于1932年首次被鉴定，自那时起，据报道它可在老年、免疫功能低下和身体虚弱的患者中引起多种感染。随着广谱抗生素的使用，弗氏柠檬酸杆菌对抗菌药物的耐药性越来越强。为了确定弗氏柠檬酸杆菌药敏性的时间变化及当前的药敏状态，我们比较了弗氏柠檬酸杆菌在两个不同时间段（1987年至1988年和1997年至1998年）的药敏情况。在这两个时间段，从台湾大学医院所有临床分离株中随机选取61株弗氏柠檬酸杆菌进行研究。比较了15种抗菌药物的最低抑菌浓度和敏感率，发现大多数弗氏柠檬酸杆菌分离株对抗假单胞菌青霉素、第一代、第二代和第三代头孢菌素、庆大霉素、妥布霉素和氨曲南耐药。结果表明，1987年至1998年期间，弗氏柠檬酸杆菌对氨基糖苷类药物和环丙沙星的敏感率显著下降。头孢吡肟、头孢匹罗、亚胺培南和美罗培南仍然是对抗弗氏柠檬酸杆菌最有效的药物。
