一项关于钙拮抗剂氨氯地平对大鼠拔牙后骨愈合影响的组织计量学研究。
A histometric study in rats of the effect of the calcium antagonist amlodipine on bone healing after tooth extraction.
作者信息
Teófilo J M, Brentegani L G, Carvalho T L
机构信息
Department of Morphology, Stomatology and Physiology, Faculdade de Odontologia de Ribeirão Preto-USP, Dental School of Ribeirão Preto, University of São Paulo, Av. do Café s/n, 14040-904 Ribeirão Preto, SP, Brazil.
出版信息
Arch Oral Biol. 2001 Apr;46(4):375-9. doi: 10.1016/s0003-9969(00)00132-1.
The purpose was to investigate whether amlodipine, a second-generation calcium antagonist used for the treatment of hypertension and angina, interferes with healing of rat alveolar bone. A progressive increase in volume density of new bone filling the socket was quantified by a histometric differential point-counting method 7-42 days after tooth extraction. The results showed a 20-30% decrease in bone volume fraction in the alveolus of amlodipine-treated animals from 7 days on, in addition to a higher (7-35%) volume fraction of connective tissue and a tendency toward an increase in the volume fraction of persisting coagulum. If confirmed in humans, the knowledge of a deleterious effect of Ca-channel blockers in hindering alveolar bone healing would be important in planning oral operations involving bone tissue, including those for device implantation.
目的是研究用于治疗高血压和心绞痛的第二代钙拮抗剂氨氯地平是否会干扰大鼠牙槽骨的愈合。拔牙后7至42天，采用组织计量学微分点计数法对填充牙槽窝的新骨体积密度的逐渐增加进行量化。结果显示，从第7天起，氨氯地平治疗组动物牙槽骨的骨体积分数降低了20%至30%，此外，结缔组织的体积分数更高（7%至35%），并且残留血凝块的体积分数有增加的趋势。如果在人体中得到证实，钙通道阻滞剂对牙槽骨愈合有有害作用这一认识，对于规划涉及骨组织的口腔手术（包括器械植入手术）将具有重要意义。
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