Kojima K, Mohamed S, Fujimaru Y, Mori Y, Kaname H, Sumida Y, Kinukawa N, Tashiro N
Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Auton Neurosci. 2000 Dec 28;86(1-2):58-64. doi: 10.1016/S1566-0702(00)00236-8.
Influence of hypothalamically induced emotional behavior on the circulating plasma volume, plasma levels of glucose, epinephrine (E), norepinephrine (NE), dopamine (DA) and cortisol were examined in awake cats under both fasted and fed conditions. Restlessness was evoked intermittently for 6 h by electrical stimulation of the anteromedial hypothalamus (AMH). Blood was sampled immediately before, 1 h after and 6 h after the start of stimulation. Changes in the plasma volume was calculated by changes of hemoglobin (Hb) and hematocrit (Ht). As the control group, another 7 cats with electrodes implanted but unstimulated were identically treated under both fasted and fed conditions. Both E and glucose levels in restlessness group once markedly increased after 1 h and then tended to decrease after 6 h, whereas NE levels in restlessness group increased after 1 h and further increased after 6 h, whether cats were fasted or fed. DA levels increased under the fasted condition of restlessness. The cortisol level markedly increased in both fasted and fed restlessness groups. The plasma volume in control group increased under the fed condition, while in restlessness group it decreased remarkably and tended to decrease more in a fasted state than in a fed state. These results indicated that AMH induced restlessness elicited marked sympatho-adrenal activation, hyperglycemia and hemoconcentration, whether cats were fasted or fed. Relationship among such responses, and the difference in responses between fasted and fed conditions were also discussed in the paper.
在禁食和进食条件下，对清醒猫下丘脑诱发的情绪行为对循环血浆容量、血浆葡萄糖、肾上腺素（E）、去甲肾上腺素（NE）、多巴胺（DA）和皮质醇水平的影响进行了研究。通过电刺激下丘脑前内侧（AMH）间歇性诱发6小时的躁动不安。在刺激开始前、开始后1小时和6小时立即采集血液样本。血浆容量的变化通过血红蛋白（Hb）和血细胞比容（Ht）的变化来计算。作为对照组，另外7只植入电极但未受刺激的猫在禁食和进食条件下接受相同的处理。无论猫是禁食还是进食，躁动不安组的E和葡萄糖水平在1小时后均一度显著升高，然后在6小时后趋于下降，而躁动不安组的NE水平在1小时后升高，在6小时后进一步升高。在禁食状态下的躁动不安时DA水平升高。禁食和进食的躁动不安组中皮质醇水平均显著升高。对照组的血浆容量在进食条件下增加，而躁动不安组的血浆容量显著减少，且在禁食状态下比进食状态下减少得更多。这些结果表明，无论猫是禁食还是进食，AMH诱发的躁动不安都会引起明显的交感-肾上腺激活、高血糖和血液浓缩。本文还讨论了这些反应之间的关系以及禁食和进食条件下反应的差异。
