Kojima K, Hirata K, Higuchi S, Akazawa K, Tashiro N
Department of Neuropsychiatry, Kyushu University, Japan.
J Auton Nerv Syst. 1995 Oct 5;55(1-2):57-64. doi: 10.1016/0165-1838(95)00024-r.
Hypothalamic stimulation applied through chronically implanted electrodes elicits several kinds of emotional behavior in conscious cats. We chose 3 kinds of emotional behavior, i.e., restlessness, threat and searching-biting. Under lightly anesthetized condition, we examined the changes of E, NE, DA and cortisol levels in arterial plasma and the cardiovascular responses (changes of systolic and diastolic blood pressure, heart rate and the occurrence of poststimulus ventricular arrhythmia) associated with electrical stimulation of specific sites within the hypothalamus. Both in restlessness and threat groups, elevation in systolic blood pressure was significantly greater and also the occurrence of ventricular arrhythmia and elevation in diastolic blood pressure tended to be greater than in the searching-biting group. Plasma E, NE, DA and cortisol increased significantly in restlessness and threat groups but remained unchanged in searching-biting and control groups. The ratios of changed values in catecholamines: delta E/delta NE, delta E/delta DA or delta NE/delta DA were not significantly different between any groups of emotional behavior. Furthermore, in the restlessness group, delta E, delta NE and delta DA all showed significant correlation with both the number of ventricular arrhythmia and changes of diastolic blood pressure; and the number of ventricular arrhythmia showed significant correlation with both the changes of diastolic blood pressure and heart rate. None of these correlations was observed in the threat or searching-biting group. These results suggested that restlessness and threat behaviors were more closely related to stress response than searching-biting behavior in cats. The differences in the endocrine and cardiovascular responses between restlessness and threat behavior were also discussed in the paper.
通过长期植入电极施加的下丘脑刺激可引发清醒猫的几种情绪行为。我们选择了3种情绪行为，即躁动、威胁和搜寻-撕咬。在轻度麻醉状态下，我们检测了动脉血浆中肾上腺素（E）、去甲肾上腺素（NE）、多巴胺（DA）和皮质醇水平的变化，以及与下丘脑特定部位电刺激相关的心血管反应（收缩压和舒张压的变化、心率以及刺激后室性心律失常的发生情况）。在躁动组和威胁组中，收缩压的升高均显著大于搜寻-撕咬组，室性心律失常的发生率以及舒张压的升高也倾向于高于搜寻-撕咬组。躁动组和威胁组的血浆E、NE、DA和皮质醇显著升高，而搜寻-撕咬组和对照组则保持不变。任何情绪行为组之间儿茶酚胺变化值的比率：ΔE/ΔNE、ΔE/ΔDA或ΔNE/ΔDA均无显著差异。此外，在躁动组中，ΔE、ΔNE和ΔDA均与室性心律失常的数量以及舒张压的变化显著相关；室性心律失常的数量与舒张压和心率的变化均显著相关。在威胁组或搜寻-撕咬组中未观察到这些相关性。这些结果表明，在猫中，躁动和威胁行为比搜寻-撕咬行为与应激反应的关系更为密切。本文还讨论了躁动和威胁行为在内分泌和心血管反应方面的差异。
