Ho B C, Laudette-Aboulhab J, Se-Thoe S Y, Chan S P, Ling A E, Leo Y S
Communicable Disease Centre, Tan Tock Seng Hospital, Moulmein Road, Singapore 308433.
Ann Acad Med Singap. 2000 Nov;29(6):708-13.
Quantitative measurement of plasma HIV-1 RNA viral load has been available in Singapore since 30 November 1996. This study investigates the relationship, in antiretroviral-naïve, HIV-positive Singapore residents, between the baseline HIV-1 RNA viral load and clinical status at the time of quantification. The association of HIV-1 RNA viral load with CD4+ T-cell counts was also studied.
HIV-1 RNA viral load was determined using Amplicor HIV-1 Monitor Test. One hundred and eighty subjects had baseline plasma HIV-1 RNA levels quantified during the period 30 November 1996 to 27 July 1998. They were classified into three clinical groups: A for asymptomatic infection (n = 110), B for symptomatic infection (n = 29) and C for AIDS (n = 41).
The differences between mean HIV-1 RNA levels were statistically significant (P < 0.001) for groups A and B (mean difference = -0.61 log10), and for groups A and C (mean difference = -0.75 log10). However, there was no statistically significant difference (P = 0.68) between groups B and C (mean difference = -0.13 log10). Of those subjects with CD4+ T-cell counts measured within 30 days of viral load quantification, there were statistically significant negative correlations between HIV-1 viral load and CD4+ T-cell counts for groups A (n = 91, r = -0.536, P < 0.01) and C (n = 34, r = -0.446, P < 0.01) but not group B (n = 26, r = -0.297, P > 0.05).
This suggest that the more advanced the phase of HIV infection, the higher the baseline plasma viral load and the lower the CD4+ T-lymphocyte counts.
自1996年11月30日起，新加坡可进行血浆HIV-1 RNA病毒载量的定量检测。本研究调查了初治的HIV阳性新加坡居民中，基线HIV-1 RNA病毒载量与定量检测时临床状态之间的关系。同时还研究了HIV-1 RNA病毒载量与CD4 + T细胞计数的关联。
使用Amplicor HIV-1监测检测法测定HIV-1 RNA病毒载量。180名受试者在1996年11月30日至1998年7月27日期间进行了基线血浆HIV-1 RNA水平的定量检测。他们被分为三个临床组：A组为无症状感染（n = 110），B组为有症状感染（n = 29），C组为艾滋病（n = 41）。
A组和B组之间（平均差异=-0.61 log10）以及A组和C组之间（平均差异=-0.75 log10）的平均HIV-1 RNA水平差异具有统计学意义（P < 0.001）。然而，B组和C组之间（平均差异=-0.13 log10）没有统计学意义上的差异（P = 0.68）。在病毒载量定量检测后30天内测量了CD4 + T细胞计数的受试者中，A组（n = 91，r = -0.536，P < 0.01）和C组（n = 34，r = -0.446，P < 0.01）的HIV-1病毒载量与CD4 + T细胞计数之间存在统计学意义上的负相关，但B组（n = 26，r = -0.297，P > 0.05）不存在。
这表明HIV感染阶段越 advanced，基线血浆病毒载量越高，CD4 + T淋巴细胞计数越低。 （注：原文中“more advanced the phase of HIV infection”表述有误，正确表述应该是“more advanced the HIV infection phase” ，译文按正确理解翻译为“HIV感染阶段越 advanced” ）
