将持续 LCMV 感染的研究进展转化为抗 HIV 免疫。
Translating insights from persistent LCMV infection into anti-HIV immunity.
机构信息
Department of Microbiology, Immunology and Molecular Genetics and the UCLA AIDS Institute, David Geffen School of Medicine, University of California-Los Angeles, CA 90095, USA.
出版信息
Immunol Res. 2010 Dec;48(1-3):3-13. doi: 10.1007/s12026-010-8162-1.
Abstract
Human immunodeficiency virus (HIV) is a major global health concern with more than 30 million individuals currently infected worldwide. To date, attempts to stimulate protective immunity to viral components of HIV have been unsuccessful in preventing or clearing infection. Lymphocytic choriomeningitis virus (LCMV) is an established murine model of persistent viral infection that has been instrumental in illuminating several critical aspects of antiviral immunity. Although virologically the course of LCMV infection differs significantly from HIV, the immune responses and regulatory mechanisms elicited by these two viruses are markedly similar. In this review we discuss important recent findings in the LCMV model, highlighting the role of host-derived proteins in shaping immune responses to persistent infections, and explore the therapeutic potential of manipulating these pathways to enhance HIV vaccination strategies.
摘要
人类免疫缺陷病毒 (HIV) 是一个全球性的主要健康关注点，目前全球有超过 3000 万人感染。迄今为止，刺激针对 HIV 病毒成分的保护性免疫以预防或清除感染的尝试都未能成功。淋巴细胞脉络丛脑膜炎病毒 (LCMV) 是一种已建立的持续性病毒感染的小鼠模型，对于阐明抗病毒免疫的几个关键方面具有重要作用。尽管从病毒学角度来看，LCMV 感染的病程与 HIV 有很大的不同，但这两种病毒引起的免疫反应和调节机制非常相似。在这篇综述中，我们讨论了 LCMV 模型中的重要新发现，强调了宿主来源蛋白在塑造对持续性感染的免疫反应中的作用，并探讨了操纵这些途径以增强 HIV 疫苗接种策略的治疗潜力。
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