Veglio F, Morra di Cella S, Schiavone D, Paglieri C, Rabbia F, Mulatero P, Chiandussi L
Department of Medicine and Experimental Oncology Hypertension Unit, S. Vito Hospital, Torino, Italy.
Clin Exp Hypertens. 2001 Jan-Feb;23(1-2):3-14. doi: 10.1081/ceh-100001192.
Hypertension is a condition where adrenergic responsiveness, sympathetic activity and adrenoceptors are somewhat altered. Many techniques are available to assess human sympathetic nervous system activity. They each present limitations and disadvantages. Characterization and subdivision of the alpha and beta-adrenoceptors, according to their localization and answer to different agonists, was facilitated in recent years by the extensive use of pharmacological and molecular biology techniques. Some adrenoceptor studies were conducted on animal models, human tissues and peripheral blood cells to assess their changes in various forms and stages of hypertension. Our group has pointed out that alpha1-adrenergic receptors expressed by human peripheral blood lymphocytes underwent changes of density in essential hypertensives, compared to normotensive control subjects. The importance of these findings could provide an assessment of alpha1-peripheral receptors with possible future clinical implications in the pathophysiology and treatment of hypertension.
高血压是一种肾上腺素能反应性、交感神经活动和肾上腺素受体有所改变的病症。有多种技术可用于评估人体交感神经系统活动。它们各自都存在局限性和缺点。近年来，通过广泛使用药理学和分子生物学技术，根据α和β肾上腺素受体的定位及对不同激动剂的反应，对其进行表征和细分变得更加容易。一些肾上腺素受体研究是在动物模型、人体组织和外周血细胞上进行的，以评估它们在高血压的各种形式和阶段中的变化。我们的研究小组指出，与血压正常的对照受试者相比，原发性高血压患者外周血淋巴细胞表达的α1肾上腺素能受体密度发生了变化。这些发现的重要性在于可能为α1外周受体评估提供依据，对高血压的病理生理学和治疗具有潜在的临床意义。
