口服维生素C对人房水抗坏血酸浓度的影响。
Effect of oral administration of vitamin C on human aqueous humor ascorbate concentration.
作者信息
Iqbal Z, Midgley J M, Watson D G, Karditsas S D, Dutton G N, Wilson W S
机构信息
Department of Pharmacy, University of Strathclyde, Glasgow G1, 1XW, UK.
出版信息
Zhongguo Yao Li Xue Bao. 1999 Oct;20(10):879-83.
AIM
To study oral administration of vitamin C on human aqueous humour ascorbate concentration.
METHODS
High performance liquid chromatography (HPLC) coupled with electrochemical detector (ECD) was used. The effect of oral administration of various doses of ascorbic acid, 0 (control), 1.0, 1.5, 2.0, 3.0, and 5.0 g, on its concentration in aqueous humour, obtained from volunteer cataract patients was studied.
RESULTS
The concentration of ascorbic acid in aqueous humour of control group (without administration of vitamin-C tablet or drug containing ascorbic acid was (254 +/- 119) mg.L-1. This study revealed that the administration of 2.0 g of ascorbic acid saturate the aqueous humour and further increase in the dose (3.0 g and 5.0 g) did not increase its concentration in aqueous humour, although its concentration was increased in plasma.
CONCLUSION
Oral administration of 2.0 g of Vc is sufficient to saturate the aqueous humour where it may be helpful in controlling the intra-ocular pressure.
目的
研究口服维生素C对人房水抗坏血酸浓度的影响。
方法
采用高效液相色谱法（HPLC）结合电化学检测器（ECD）。研究了口服不同剂量（0（对照组）、1.0、1.5、2.0、3.0和5.0 g）抗坏血酸对从志愿白内障患者获取的房水中其浓度的影响。
结果
对照组（未服用维生素C片或含抗坏血酸药物）房水中抗坏血酸浓度为（254±119）mg·L⁻¹。本研究表明，服用2.0 g抗坏血酸可使房水饱和，剂量进一步增加（3.0 g和5.0 g）虽可使血浆中抗坏血酸浓度升高，但房水中其浓度并未增加。
结论
口服2.0 g维生素C足以使房水饱和，这可能有助于控制眼压。
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