Samorajski T
J Comp Neurol. 1975 May 15;161(2):255-67. doi: 10.1002/cne.901610208.
Brain tissue was examined for morphological changes at 12 and 16 months after focal irradiation of the brain in female mice. Irradiation was performed with deuteron beams derived from the 60-inch Brookhaven cyclotron at a rate of 1925 rad second -minus 1 though an anti-Bragg device which produced uniform exposure. Experimental animals received a dose of 10,000 rad, covering a 9 by 5 mm area over the skull and extending into the brain from a depth of about 2 mm. An additional group of animals served as sham-irradiated controls. Histological studies revealed extensive cell loss, vacuolation, and prominent vascular changes in irradiated regions of the brain at 16 months post-irradiation. Ultrastructural examination of brain tissue at 12 and 16 months after irradiation revealed the presence of unusual elongated mitochondria with parallel arrays of cristae. Altered mitochondria were more prevalent at the longer post-irradiation interval.
对雌性小鼠脑部进行局部照射后12个月和16个月，检查脑组织的形态学变化。使用布鲁克海文60英寸回旋加速器产生的氘核束进行照射，照射速率为1925拉德每秒-1，通过一个产生均匀照射的反布拉格装置进行。实验动物接受10000拉德的剂量，覆盖颅骨上9×5毫米的区域，并从约2毫米的深度延伸至脑内。另一组动物作为假照射对照。组织学研究显示，照射后16个月，脑部照射区域出现广泛的细胞丢失、空泡化和明显的血管变化。照射后12个月和16个月对脑组织的超微结构检查显示存在异常的细长线粒体，其嵴呈平行排列。照射后间隔时间越长，线粒体改变越普遍。
