Valente G, Pagano M, Carrozzo M, Carbone M, Bobba V, Palestro G, Gandolfo S
Department of Medical Sciences, University of Eastern Piedmont, Novara, Italy.
J Oral Pathol Med. 2001 Mar;30(3):135-40. doi: 10.1034/j.1600-0714.2001.300302.x.
Transformation in squamous cell carcinoma (SCC) may occur in a small percentage of patients affected by oral lichen planus (OLP), but the pathogenesis remains to be elucidated. Overexpression of p53 protein was investigated immunohistochemically in 28 cases of OLP, followed up by sequential biopsies for up to 96 months. In 15 cases (Group 1), no dysplastic changes or neoplastic transformation occurred during the follow-up period; in 7 cases, OLP and SCC were synchronously observed (Group 2), whereas in another 6 cases (Group 3) SCC developed several months or years after diagnosis of OLP. The percentage of p53-positive epithelial cells at first diagnosis was significantly higher in the cases of Groups 2 and 3 than in those of Group 1. In contrast, evaluation of growth fraction by MIB-1 monoclonal antibody did not show any statistical differences among the three groups. Although no conclusions can be drawn about the molecular pathway leading to neoplastic transformation of OLP, or about the role of p53, the results indicate that immunohistochemical evaluation of p53 expression may be a practical tool to select cases of OLP with a high risk of neoplastic transformation.
鳞状细胞癌（SCC）可在一小部分口腔扁平苔藓（OLP）患者中发生，但发病机制仍有待阐明。对28例OLP患者进行了p53蛋白过表达的免疫组织化学研究，并进行了长达96个月的连续活检随访。15例（第1组）在随访期间未发生发育异常改变或肿瘤转化；7例同时观察到OLP和SCC（第2组），而另外6例（第3组）在OLP诊断数月或数年之后发生了SCC。第2组和第3组病例初次诊断时p53阳性上皮细胞的百分比显著高于第1组。相比之下，用MIB-1单克隆抗体评估增殖分数在三组之间未显示任何统计学差异。虽然对于导致OLP肿瘤转化的分子途径或p53的作用无法得出结论，但结果表明p53表达的免疫组织化学评估可能是选择具有肿瘤转化高风险OLP病例的实用工具。
