Nicolatou-Galitis O, Kitra V, Van Vliet-Constantinidou C, Peristeri J, Goussetis E, Petropoulos D, Grafakos S
Department of Oral Pathology and Surgery, School of Dentistry, University of Athens, Greece.
J Oral Pathol Med. 2001 Mar;30(3):148-53. doi: 10.1034/j.1600-0714.2001.300304.x.
The oral manifestations of chronic graft-versus-host disease (cGVHD) in eight allogeneic bone marrow transplant (BMT) paediatric recipients were studied clinically, and lip biopsies were performed in seven of them. A prominent lichenoid reaction was observed in four patients, two with accompanying ulceration. Superficial mucoceles were present in three children. Clinically obvious xerostomia was seen in seven patients. Lip biopsies were positive and correlated with the clinical manifestations. Both clinical and histological findings confirmed the diagnosis of cGVHD. In three additional children, with systemic manifestations indicating cGVHD, the oral mucosa was clinically and histologically normal, and the systemic manifestations were, thus, attributed to drug reactions. The above findings indicate the high value of oral examination in diagnosing or confirming paediatric cGVHD. Superficial mucoceles, reported for the first time in paediatric recipients, seem to be important in the early diagnosis of cGVHD.
对8名接受异基因骨髓移植（BMT）的儿科患者的慢性移植物抗宿主病（cGVHD）的口腔表现进行了临床研究，并对其中7名患者进行了唇部活检。4名患者观察到明显的苔藓样反应，其中2名伴有溃疡。3名儿童出现浅表黏液囊肿。7名患者临床上有明显的口干症状。唇部活检呈阳性，且与临床表现相关。临床和组织学检查结果均证实了cGVHD的诊断。另外3名有提示cGVHD全身表现的儿童，其口腔黏膜在临床和组织学上均正常，因此全身表现归因于药物反应。上述发现表明口腔检查在诊断或确诊儿科cGVHD方面具有很高的价值。浅表黏液囊肿在儿科受者中首次报道，似乎对cGVHD的早期诊断很重要。
