Schubert M M, Sullivan K M, Morton T H, Izutsu K T, Peterson D E, Flournoy N, Truelove E L, Sale G E, Buckner C D, Storb R
Arch Intern Med. 1984 Aug;144(8):1591-5.
Sixty patients were studied 180 to 500 days after allogeneic marrow transplantation to determine if late oral abnormalities were associated with the presence of chronic graft-v-host disease (GVHD). Lip and intraoral mucosal surfaces were evaluated for color, keratinization, atrophy, and erythema. Subjective complaints of oral pain and xerostomia were also recorded. Abnormalities were scored on a scale of 0 to 3 and tested for association with GVHD by chi 2 test. Oral manifestations most strongly associated with chronic GVHD included atrophy and erythema or lichenoid lesions of the buccal and labial mucosa and oral pain. Oral manifestations resembled several naturally occurring autoimmune disorders. Recognition of these changes can aid in the clinical diagnosis and assessment of established chronic GVHD.
对60例异基因骨髓移植术后180至500天的患者进行了研究，以确定晚期口腔异常是否与慢性移植物抗宿主病（GVHD）的存在有关。对唇部和口腔内黏膜表面的颜色、角化、萎缩和红斑情况进行了评估。还记录了口腔疼痛和口干的主观症状。异常情况按0至3分进行评分，并通过卡方检验来检测与GVHD的相关性。与慢性GVHD最密切相关的口腔表现包括颊黏膜和唇黏膜的萎缩、红斑或苔藓样病变以及口腔疼痛。这些口腔表现类似于几种自然发生的自身免疫性疾病。认识到这些变化有助于对已确诊的慢性GVHD进行临床诊断和评估。
