Balasubramaniam Ramesh, Alawi Faizan, DeRossi Scott
Department of Oral Medicine, School of Dental Medicine, University of Pennsylvania, Philadelphia, USA.
Gen Dent. 2009 Jan-Feb;57(1):82-8.
Graft-versus-host disease (GVHD) is a common complication among allogeneic hematopoietic cell transplant recipients. Chronic GVHD (cGVHD) has numerous clinical manifestations and the oral cavity is almost always involved. Common oral manifestations include diffuse mucosal erythema and atrophy, lichenoid lesions, pain, and xerostomia. This article reports the case of a 40-year-old man with a history of allogeneic hematopoietic cell transplantation who developed cGVHD. In addition to diffuse oral mucosal erythema and lichenoid-appearing lesions, he also developed numerous persistent painful superficial mucoceles. The superficial mucoceles were refractory to treatment with topical steroids; however, subsequent treatment with triamcinolone intra-lesional injections decreased their quantity, size, and symptoms.
移植物抗宿主病（GVHD）是异基因造血细胞移植受者中常见的并发症。慢性移植物抗宿主病（cGVHD）有多种临床表现，口腔几乎总是受累。常见的口腔表现包括弥漫性黏膜红斑和萎缩、苔藓样病变、疼痛和口干。本文报告了一例40岁有同种异体造血细胞移植病史并发生cGVHD的男性病例。除了弥漫性口腔黏膜红斑和苔藓样病变外，他还出现了许多持续性疼痛的浅表黏液囊肿。浅表黏液囊肿对局部类固醇治疗无效；然而，随后的曲安奈德病灶内注射治疗减少了其数量、大小和症状。
