Inorganic and Analytical Chemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece.
Bioinorg Chem Appl. 2010;2010:718606. doi: 10.1155/2010/718606. Epub 2010 May 12.
The novel diphenyltin(IV) compound [Ph(2)(HyFoSc)Sn] (2), where H(2)HyFoSc (1) is 3-hydroxy-2-formylpyridine semicarbazone, was prepared and characterized by vibrational and NMR ((1)H, (13)C) spectroscopy. The structure of [Ph(2)(HyFoSc)Sn] was confirmed by single-crystal X-ray crystallography. The doubly deprotonated ligand is coordinated to the tin atom through the enolic-oxygen, the azomethine-nitrogen, and phenolic-oxygen, and so acts as an anionic tridentate ligand with the ONO donors. Two carbon atoms complete the fivefold coordination at the tin(IV) center. Intermolecular hydrogen bonding, C-H --> pi, and pi --> pi interactions combine to stabilize the crystal structure. Compounds 1 and 2 have been evaluated for antiproliferative activity in vitro against the cells of three human tumor cell lines: MCF-7 (human breast cancer cell line), T24 (bladder cancer cell line), A549 (nonsmall cell lung carcinoma), and a mouse fibroblast L-929 cancer cell line.
新型二苯基锡(IV)化合物[Ph(2)(HyFoSc)Sn]（2），其中 H(2)HyFoSc（1）为 3-羟基-2-甲酰基吡啶缩氨脲，通过振动和 NMR（（1）H，（13）C）光谱进行了制备和表征。[Ph(2)(HyFoSc)Sn]的结构通过单晶 X 射线晶体学得到确认。双去质子化配体通过烯醇氧、亚氨基氮和酚氧与锡原子配位，因此作为阴离子三齿配体，具有 ONO 供体。两个碳原子在锡(IV)中心完成五重配位。分子间氢键、C-H --> pi 和 pi --> pi 相互作用结合起来稳定了晶体结构。化合物 1 和 2 已在体外针对三种人肿瘤细胞系（MCF-7（人乳腺癌细胞系）、T24（膀胱癌细胞系）、A549（非小细胞肺癌）和小鼠成纤维细胞 L-929 癌细胞系）的增殖活性进行了评估。
