Roushdy-Hammady I, Siegel J, Emri S, Testa J R, Carbone M
Lancet. 2001 Feb 10;357(9254):444-5. doi: 10.1016/S0140-6736(00)04013-7.
Erionite present in stones used to build the villages of Karain and Tuzköy, Turkey, mined from nearby caves, is purported to cause mesothelioma in half of the villagers. We constructed genetic epidemiology maps to test whether some villagers were genetically predisposed to mesothelioma. Analysis of a six-generation extended pedigree of 526 individuals showed that mesothelioma was genetically transmitted, probably in an autosomal dominant way. This finding should lead to preventive strategies to lower the incidence of mesothelioma in future generations, and close monitoring of high-risk individuals might allow early detection and cure.
在土耳其卡赖恩和图兹科伊村庄用于建房的石头中存在的毛沸石，是从附近洞穴开采而来，据称致使一半村民患上间皮瘤。我们构建了基因流行病学图谱，以测试是否有些村民在基因上易患间皮瘤。对一个由526人组成的六代大家庭谱系进行分析后发现，间皮瘤是以常染色体显性方式进行基因遗传的。这一发现应能催生预防策略，以降低后代间皮瘤的发病率，对高危个体进行密切监测或许能实现早期检测与治愈。
