Bariş B, Demir A U, Shehu V, Karakoca Y, Kisacik G, Bariş Y I
Department of Medicine, University of Illinois, College of Medicine, Chicago, USA.
J Environ Pathol Toxicol Oncol. 1996;15(2-4):183-9.
We studied the mortality in three villages in the Cappadocian region of Central Anatolia, Karain, Tuzköy, and Sarihidir, which were exposed to fibrous zeolite (erionite), a known carcinogen more potent than the amphibole asbestos. Between 1970 and 1994, there were 305 deaths in Karain, and 177 (58%) were cancer related, including 150 (49.2%) malignant pleural mesothelioma, seven (2.3%) malignant peritoneal mesothelioma, and six (1%) gastroesophageal carcinoma. Four deaths (1.3%) from lung cancer included two nonsmoking females. There were three cases (1%) of leukemia and six of other malignancies (1.9%). Between 1980 and 1994, there were 519 deaths in Tuzköy (T) and Sarihidir (S) (T = 432, S = 87). Of these, 257 were cancer related, and included 120 cases of malignant pleural mesothelioma and 64 cases of malignant peritoneal mesothelioma. Intraabdominal carcinoma was noted in 29 patients and 14 patients had lung cancer (four of whom were nonsmoking women). There were five cases of gastroesophageal cancer, five deaths due to leukemia, and 16 cases of various malignancies. These mortality figures support the hypothesis that erionite fibers cause cancer other than mesothelioma and lung cancer. Mineralogic analyses of the tissues should be performed to demonstrate this relationship.
我们研究了安纳托利亚中部卡帕多西亚地区的三个村庄——卡赖恩、图兹科伊和萨里希迪尔的死亡率情况，这些村庄接触到了纤维沸石（毛沸石），这是一种已知的致癌物，其致癌性比闪石石棉更强。1970年至1994年间，卡赖恩有305人死亡，其中177人（58%）与癌症相关，包括150人（49.2%）患恶性胸膜间皮瘤、7人（2.3%）患恶性腹膜间皮瘤以及6人（1%）患胃食管癌。4例（1.3%）肺癌死亡病例中有2名不吸烟女性。有3例（1%）白血病病例和6例其他恶性肿瘤病例（1.9%）。1980年至1994年间，图兹科伊（T）和萨里希迪尔（S）有519人死亡（T = 432，S = 87）。其中，257人与癌症相关，包括120例恶性胸膜间皮瘤病例和64例恶性腹膜间皮瘤病例。29名患者被诊断患有腹内癌，14名患者患有肺癌（其中4名是不吸烟女性）。有5例胃食管癌病例、5例白血病死亡病例以及16例各种恶性肿瘤病例。这些死亡率数据支持了毛沸石纤维会引发间皮瘤和肺癌以外其他癌症的假设。应进行组织的矿物学分析以证实这种关系。
