血清镁和电解质检测作为急性心肌梗死管理中辅助心脏生物标志物的前景。

The prospect of serum magnesium and an electrolyte panel as an adjuvant cardiac biomarker in the management of acute myocardial infarction.

作者信息

Ramasamy Ramesh, Murugaiyan Sathish Babu, Gopal Niranjan, Shalini Rachel

机构信息

Professor & Head, Department of Biochemistry, Mahathma Gandhi Medical College and Research Institute Pillayarkuppam Puducherry - 605 402, India .

出版信息

J Clin Diagn Res. 2013 May;7(5):817-20. doi: 10.7860/JCDR/2013/5524.2947. Epub 2013 Mar 21.

DOI:10.7860/JCDR/2013/5524.2947

PMID:23814718

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3681045/

Abstract

BACKGROUND

Ischemic heart disease accounts 12.2% deaths worldwide. Serum magnesium (Mg+) status is often ignored in Acute Myocardial Infarction (AMI). Studies showed alterations in the levels of serum electrolytes including magnesium in AMI.

AIM

To evaluate serum Mg+ and other electrolytes as adjuvant markers in the diagnosis of AMI.

DESIGN AND SETTINGS

Case control study was conducted in South Indian male population with AMI within six hours of onset of symptoms.

PATIENTS AND METHODS

Study includes sixty patients with AMI and 100 controls. Serum electrolytes were estimated using electrolyte analyzer. Data were compared by using student't' test. ROC was drawn to find out optimum cutoff for diagnosing AMI. Pearson's correlation was done to see the association among the markers.

RESULTS

Serum Ca, Mg, K and Na electrolytes were significantly lower ('p'<0.001) in AMI. Ca:Mg, K:Mg, and Na:K ratios were significantly higher when compared to controls ('p'<0.001). There was significant correlation of serum Mg levels with other cardiac markers (Total CK, CK-Mb, Troponin -T) of AMI ('p' <0.05).ROC analysis of Na:Mg (40.9), Ca:Mg (3.43) and K:Mg (2.74) ratios showed optimum cutoffs in diagnosis of AMI.

CONCLUSION

Serum Mg, Ca:mg, K:mg and Na:K ratios could be useful adjuvant markers in diagnosis of AMI.

摘要

背景

缺血性心脏病在全球范围内导致12.2%的死亡。血清镁（Mg+）水平在急性心肌梗死（AMI）中常常被忽视。研究表明，AMI患者血清电解质（包括镁）水平会发生改变。

目的

评估血清Mg+及其他电解质作为辅助标志物在AMI诊断中的作用。

设计与地点

对症状发作6小时内的南印度男性AMI患者进行病例对照研究。

患者与方法

研究纳入60例AMI患者和100例对照。使用电解质分析仪测定血清电解质。采用学生t检验比较数据。绘制ROC曲线以确定诊断AMI的最佳临界值。进行Pearson相关性分析以观察各标志物之间的关联。

结果

AMI患者血清钙、镁、钾和钠电解质水平显著降低（“p”<0.001）。与对照组相比，钙：镁、钾：镁和钠：钾比值显著升高（“p”<0.001）。AMI患者血清镁水平与其他心脏标志物（总肌酸激酶、肌酸激酶同工酶、肌钙蛋白-T）存在显著相关性（“p”<0.05）。钠：镁（40.9）、钙：镁（3.43）和钾：镁（2.74）比值的ROC分析显示了诊断AMI的最佳临界值。