Gupta S, Raina V, Jain P, Gujral S, Kumar R
Department of Medical Oncology, Institute Rotary Cancer Hospital (IRCH), All India Institute of Medical Sciences (AIIMS), New Delhi-110 029, India.
J Assoc Physicians India. 2000 Jun;48(6):639-40.
Secondary leukemias are an increasingly well recognized complication of cancer chemotherapy. We report on the development of undifferentiated leukemia in a forty one year lady, eighteen months after treatment of gastric cancer with 5-fluorouracil (5 FU), doxorubicin and mitomycin C. She developed progressive weakness and pancytopenia over a period of few months. Leukemic blasts which were undifferentiated by immunophenotyping were seen in her peripheral blood. She died of intracranial haemorrhage during induction chemotherapy for the leukemia. Undifferentiated leukemia is a rare complication of FAM chemotherapy for gastric cancer.
继发性白血病是癌症化疗中一种日益被广泛认识的并发症。我们报告了一位41岁女性在接受5-氟尿嘧啶（5-FU）、阿霉素和丝裂霉素C治疗胃癌18个月后发生未分化白血病的情况。在几个月的时间里，她逐渐出现进行性虚弱和全血细胞减少。其外周血中可见免疫表型未分化的白血病原始细胞。她在白血病诱导化疗期间死于颅内出血。未分化白血病是FAM方案治疗胃癌罕见的并发症。
