Yumoto Y, Okuda T, Shimizu S, Kawase K
Division of Hematology and Cancer Chemotherapy, Nagahama General City Hospital.
Gan To Kagaku Ryoho. 1996 Jan;23(1):107-10.
A 50-year-old male was admitted to our hospital with severe malaise and lumbar pain. He suffered from diffuse bone metastasis of gastric cancer (mod. tub. adenocarcinoma) and DIC. In order to palliate his severe bone pain and bleeding tendency, FAM (5-fluorouracil 600 mg/body day 1, 7, 29, 36; doxorubicin 40 mg/body day 1, 29; and mitomycin C 12 mg/body day 1) combination chemotherapy was used. After administration of FAM therapy, bone pain and bleeding tendency due to DIC disappeared. For three months after initiation of chemotherapy, the patient's quality of life was maintained fairly well. Adverse reactions of FAM therapy were only appetite loss for several days. FAM therapy might be a useful regimen for palliation of bone pain and DIC due to diffuse bone metastasis of gastric cancer.
一名50岁男性因严重不适和腰痛入院。他患有胃癌（中度管状腺癌）弥漫性骨转移和弥散性血管内凝血（DIC）。为缓解其严重的骨痛和出血倾向，采用了FAM（氟尿嘧啶600mg/体，第1、7、29、36天；阿霉素40mg/体，第1、29天；丝裂霉素C 12mg/体，第1天）联合化疗。给予FAM治疗后，DIC所致的骨痛和出血倾向消失。化疗开始后的三个月里，患者的生活质量维持得相当好。FAM治疗的不良反应仅为持续数天的食欲减退。FAM治疗可能是缓解胃癌弥漫性骨转移所致骨痛和DIC的一种有效方案。
