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硫酸化和非硫酸化石胆酸及其甘氨酸和牛磺酸共轭物的薄层色谱分离

Thin-layer chromatographic separation of sulfated and nonsulfated lithocholic acids and their glycine and taurine conjugates.

作者信息

Cass O W, Cowen A E, Hofmann A F, Coffin S B

出版信息

J Lipid Res. 1975 Mar;16(2):159-60.

PMID:1127355
Abstract

A method for superior thin-layer chromatographic separation of lithocholic acid and its N-glycine and N-taurine conjugates, as well as their respective 3alpha-sulfates, is described. A solvent system of chloroform-methanol-acetic acid-water 65:24:15:9 (v/v) is used with air-dried plates of silicic acid containing calcium sulfate (10% by weight) under conditions of chamber saturation.

摘要

描述了一种用于高效薄层色谱分离石胆酸及其N-甘氨酸和N-牛磺酸共轭物，以及它们各自的3α-硫酸盐的方法。使用氯仿-甲醇-乙酸-水65:24:15:9（v/v）的溶剂系统，在腔室饱和条件下，于含有硫酸钙（重量百分比为10%）的硅胶空气干燥板上进行分离。

相似文献

1
Thin-layer chromatographic separation of sulfated and nonsulfated lithocholic acids and their glycine and taurine conjugates.硫酸化和非硫酸化石胆酸及其甘氨酸和牛磺酸共轭物的薄层色谱分离
J Lipid Res. 1975 Mar;16(2):159-60.
2
Thin-layer chromatographic separation of conjugates of ursodeoxycholic acid from those of litho-, chenodeoxy-, deoxy-, and cholic acids.熊去氧胆酸的缀合物与石胆酸、鹅去氧胆酸、脱氧胆酸和胆酸的缀合物的薄层色谱分离。
J Lipid Res. 1981 May;22(4):712-4.
3
Semiquantitative measurement of lithocholic acid compounds in bile from patients with gallstones, before and during treatment with chenodeoxycholic acid.胆结石患者胆汁中石胆酸化合物在鹅去氧胆酸治疗前及治疗期间的半定量测量。
Scand J Gastroenterol. 1976;11(5):497-504.
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Separation of conjugated and unconjugated bile acids by thin-layer chromatography.通过薄层色谱法分离结合型和非结合型胆汁酸。
Clin Chim Acta. 1976 Jul 1;70(1):197-9. doi: 10.1016/0009-8981(76)90023-1.
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Silicic acid thin-layer chromatography of conjugated and free bile acids.结合型和游离型胆汁酸的硅酸薄层色谱法。
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Synthesis of sulfate esters of lithocholic acid, glycolithocholic acid, and taurolithocholic acid with sulfur trioxide-triethylamine.用三氧化硫-三乙胺合成石胆酸、甘氨石胆酸和牛磺石胆酸的硫酸酯
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Metabolism of lethocholate in healthy man. I. Biotransformation and biliary excretion of intravenously administered lithocholate, lithocholylglycine, and their sulfates.健康人体内鹅去氧胆酸盐的代谢。I. 静脉注射鹅去氧胆酸、鹅去氧胆酰甘氨酸及其硫酸盐的生物转化和胆汁排泄。
Gastroenterology. 1975 Jul;69(1):59-66.
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Isolation and purification of lithocholic acid metabolites produced by the intestinal microflora.肠道微生物群产生的石胆酸代谢产物的分离与纯化。
J Chromatogr. 1977 Mar 21;133(2):327-34. doi: 10.1016/s0021-9673(00)83490-1.
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Improved extraction procedure for determination of bile acids in faeces.用于粪便中胆汁酸测定的改进提取方法。
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Separation of individual sulfated bile acid conjugates as calcium complexes using reversed-phase partition thin-layer chromatography.使用反相分配薄层色谱法将单个硫酸化胆汁酸共轭物分离为钙络合物。
J Lipid Res. 1979 Aug;20(6):789-95.

引用本文的文献

1
Analysis of conjugated bile acids by high performance liquid chromatography and mass spectrometry.采用高效液相色谱法和质谱法分析结合型胆汁酸。
Lipids. 1983 Jan;18(1):90-5. doi: 10.1007/BF02534697.
2
Lithocholate metabolism during chemotherapy for gallstone dissolution. 2. Absorption and sulphation.胆结石溶解化疗期间石胆酸盐的代谢。2. 吸收与硫酸化作用
Gut. 1976 Jun;17(6):413-9. doi: 10.1136/gut.17.6.413.
3
Synthesis of bile acid monosulphates by the isolated perfused rat kidney.离体灌注大鼠肾脏合成胆汁酸单硫酸盐。
Biochem J. 1976 May 15;156(2):339-45. doi: 10.1042/bj1560339.
4
The role of tubular reabsorption in the renal excretion of bile acids.肾小管重吸收在胆汁酸肾排泄中的作用。
Biochem J. 1977 Jul 15;166(1):65-73. doi: 10.1042/bj1660065.
5
Separation of sulfated bile acids by high-performance liquid chromatography.通过高效液相色谱法分离硫酸化胆汁酸。
Lipids. 1978 Dec;13(12):908-9. doi: 10.1007/BF02533848.
6
Bile acid conjugation in the chimpanzee: effective sulfation of lithocholic acid.黑猩猩体内的胆汁酸结合：石胆酸的有效硫酸化作用。
Arch Toxicol. 1978 Apr 27;40(2):109-18. doi: 10.1007/BF01891965.
7
Faecal bile acid loss and bile acid pool size during short-term treatment with ursodeoxycholic and chenodeoxycholic acid in patients with radiolucent gallstones.熊去氧胆酸和鹅去氧胆酸短期治疗透光性胆结石患者期间的粪便胆汁酸流失及胆汁酸池大小
Gut. 1979 Aug;20(8):698-704. doi: 10.1136/gut.20.8.698.