Freeman V L, Meydani M, Yong S, Pyle J, Durazo-Arvizu R, Liao Y, Flanigan R C, Waters W B
Midwest Center for Health Services and Policy Research, Department of Veterans Affairs, Edward Hines, Jr. Hospital, Hines, IL 60141, USA.
Am J Clin Nutr. 2001 Apr;73(4):815-20. doi: 10.1093/ajcn/73.4.815.
Dietary fatty acids may influence prostate carcinogenesis. Although the standard for assessing dietary effects in humans is the semiquantitative food-frequency questionnaire, the extent to which self-reported intake correctly ranks prostatic exposure is unknown.
The objective was to examine the correlation between reported intakes of different fatty acids and their concentrations in prostate tissue.
This was a cross-sectional study of 52 men undergoing surgical resection of the prostate gland. Usual dietary intake of saturated, total unsaturated, oleic, and linoleic fatty acids over the previous year was estimated with use of a 122-item version of the Health Habits and History Questionnaire. Concentrations in prostate tissue were measured directly by use of gas chromatography in healthy tissue collected at the time of surgery and were expressed as a percentage of total fatty acids. Correlations with 4 measures of dietary intake [g/d, g/d adjusted for total daily energy intake, % of total fat (as g/d), and % of total energy] were evaluated by Spearman's rank-order correlation coefficients.
Linoleic acid concentrations in prostate tissue were significantly correlated with dietary intake expressed as g/d adjusted for total energy [r = 0.29 (95% CI: 0.03, 0.49), P = 0.04], % of total fat [r = 0.36 (0.14, 0.550), P = 0.008], and % of total energy [r = 0.28 (0.04, 0.49), P = 0.042], but not as g/d. Although mean concentrations of saturated, total unsaturated, and oleic fatty acids in prostate tissue resembled mean intakes for the group, prostatic concentrations did not correlate with individual intakes.
Self-reported intake of fatty acids is a satisfactory marker of prostatic exposure at the group level, but, with the exception of linoleic acid, does not correctly rank individuals with respect to intensity of exposure.
膳食脂肪酸可能影响前列腺癌的发生。虽然评估人类膳食影响的标准是半定量食物频率问卷，但自我报告的摄入量对前列腺暴露程度的正确排序程度尚不清楚。
目的是研究不同脂肪酸的报告摄入量与其在前列腺组织中的浓度之间的相关性。
这是一项对52名接受前列腺手术切除的男性进行的横断面研究。使用122项版本的健康习惯和病史问卷估计前一年饱和、总不饱和、油酸和亚油酸的通常膳食摄入量。在手术时收集的健康组织中，通过气相色谱法直接测量前列腺组织中的浓度，并表示为总脂肪酸的百分比。通过Spearman等级相关系数评估与4种膳食摄入量测量值[克/天、根据每日总能量摄入量调整后的克/天、总脂肪的百分比（以克/天计）和总能量的百分比]的相关性。
前列腺组织中亚油酸浓度与根据总能量调整后的克/天表示的膳食摄入量显著相关[r = 0.29（95%CI：0.03，0.49），P = 0.04]、总脂肪的百分比[r = 0.36（0.14，0.550），P = 0.008]和总能量的百分比[r = 0.28（0.04，0.49），P = 0.042]，但与克/天无关。虽然前列腺组织中饱和、总不饱和和油酸的平均浓度与该组的平均摄入量相似，但前列腺浓度与个体摄入量无关。
自我报告的脂肪酸摄入量在群体水平上是前列腺暴露的一个令人满意的标志物，但除亚油酸外，不能根据暴露强度对个体进行正确排序。
