van de Beek W J T, Remarque E J, Westendorp R G J, van Hilten J J
Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands Department of Gerontology, Leiden University Medical Center, Leiden, The Netherlands Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Pain. 2001 Apr;91(3):259-261. doi: 10.1016/S0304-3959(00)00443-7.
Complex regional pain syndrome (CRPS) is a disabling disease characterized by the classic symptoms and signs of inflammation. In this study we investigated the innate cytokine profile in patients with CRPS to determine a possible role of the immune system in the pathophysiology of CRPS. The cytokine profile before and after lipopolysaccharide and thrombin stimulation was determined in 26 severely affected CRPS patients and 20 healthy controls. No difference in the production of pro- and anti- inflammatory cytokines between patients and controls was found. Hence, our results do not support a role of genetic factors responsible for the cytokine profile in the pathophysiology of CRPS. These findings encourage further investigations of mechanisms responsible for neurogenic-induced inflammation.
复杂性区域疼痛综合征（CRPS）是一种以炎症的典型症状和体征为特征的致残性疾病。在本研究中，我们调查了CRPS患者的先天性细胞因子谱，以确定免疫系统在CRPS病理生理学中的可能作用。测定了26例重度CRPS患者和20名健康对照者在脂多糖和凝血酶刺激前后的细胞因子谱。患者和对照者之间促炎和抗炎细胞因子的产生没有差异。因此，我们的结果不支持遗传因素在CRPS病理生理学中对细胞因子谱起作用。这些发现鼓励进一步研究神经源性炎症的机制。
