Haider B, Yeh C K, Thomas G, Oldewurtel H A, Lyons M M, Regan T J
Trans Assoc Am Physicians. 1978;91:197-203.
We have demonstrated that in rhesus monkeys, 18 months of diabetes alters the end-diastolic pressure, end-diastolic volume relations without hypertrophy. Accumulation of collagen in the myocardial interstitium was the apparent basis for abnormal left ventricular performance. Neither collagen concentration nor left ventricular performance were signigicantly affected by dietary lipid composition. These myocardial abnormalities occurred at a stage when coronary atherosclerosis was limited. However, the relative influence of coronary atherosclerosis and myocardial alterations during more prolonged lipid feeding remains to be determined.
我们已经证明，在恒河猴中，18个月的糖尿病会改变舒张末期压力、舒张末期容积关系，且无心肌肥厚。心肌间质中胶原蛋白的积累是左心室功能异常的明显基础。膳食脂质成分对胶原蛋白浓度和左心室功能均无显著影响。这些心肌异常发生在冠状动脉粥样硬化受限的阶段。然而，在更长时间的脂质喂养过程中，冠状动脉粥样硬化和心肌改变的相对影响仍有待确定。
