Brooks W M, Friedman S D, Gasparovic C
Clinical and Magnetic Resonance Research Center; Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, 87131, USA.
J Head Trauma Rehabil. 2001 Apr;16(2):149-64. doi: 10.1097/00001199-200104000-00005.
Magnetic resonance spectroscopy (MRS) offers a unique non-invasive approach for assessing the metabolic status of the brain in vivo and is particularly suited to studying traumatic brain injury (TBI). In particular, MRS provides a noninvasive means for quantifying such neurochemicals as N-acetylaspartate (NAA), creatine, phosphocreatine, choline, lactate, myo-inositol, glutamine, glutamate, adenosine triphosphate (ATP), and inorganic phosphate in humans following TBI and in animal models. Many of these chemicals have been shown to be perturbed following TBI. NAA, a marker of neuronal integrity, has been shown to be reduced following TBI, reflecting diffuse axonal injury or metabolic depression, and concentrations of NAA predict cognitive outcome. Elevation of choline-containing compounds indicates membrane breakdown or inflammation or both. MRS can also detect alterations in high energy phosphates reflecting the energetic abnormalities seen after TBI. Accordingly, MRS may be useful to monitor cellular response to therapeutic interventions in TBI.
磁共振波谱（MRS）为在体评估大脑代谢状态提供了一种独特的非侵入性方法，特别适用于研究创伤性脑损伤（TBI）。具体而言，MRS为定量人类TBI后及动物模型中的神经化学物质提供了一种非侵入性手段，这些神经化学物质包括N-乙酰天门冬氨酸（NAA）、肌酸、磷酸肌酸、胆碱、乳酸、肌醇、谷氨酰胺、谷氨酸、三磷酸腺苷（ATP）和无机磷酸盐。已证实其中许多化学物质在TBI后会发生紊乱。NAA作为神经元完整性的标志物，在TBI后已被证实会减少，反映出弥漫性轴突损伤或代谢抑制，且NAA浓度可预测认知结果。含胆碱化合物的升高表明细胞膜破裂或炎症或两者皆有。MRS还可检测高能磷酸盐的变化，反映TBI后出现的能量异常。因此，MRS可能有助于监测TBI中细胞对治疗干预的反应。
