Yousif B, Nelson J
Clinical Medical Services Department, Saudi Aramco-Dhahran Health Center, Saudi Aramco Medical Services Organization, Dhahran, Saudi Arabia.
Am J Nephrol. 2001 Jan-Feb;21(1):66-8. doi: 10.1159/000046223.
Brucellosis is an intracellular bacterial infection contracted by consuming raw milk or by contact with infected cattle. Neurobrucellosis is a rather rare manifestation of brucellosis and has protean clinical presentations characterized by meningoencephalitis, myelitis, myelopathies, subarachnoid hemorrhage and psychiatric manifestations. A depressed immune status is believed to be a risk factor for developing neurobrucellosis. We report a case of neurobrucellosis in a patient 13 years after a cadaveric renal transplantation. Even though a Brucella organism was not isolated from body fluids she satisfied other criteria for establishing the diagnosis. Treatment with doxycycline and rifampin led to a clinical cure as well as to marked improvement in the Brucella titer.
布鲁氏菌病是一种通过饮用生牛奶或接触受感染的牛而感染的细胞内细菌感染。神经型布鲁氏菌病是布鲁氏菌病较为罕见的一种表现形式，具有多种临床表现，其特征为脑膜脑炎、脊髓炎、脊髓病、蛛网膜下腔出血和精神症状。免疫状态低下被认为是发生神经型布鲁氏菌病的一个危险因素。我们报告一例尸体肾移植13年后发生神经型布鲁氏菌病的病例。尽管在患者体液中未分离出布鲁氏菌，但她符合确立诊断的其他标准。使用强力霉素和利福平治疗使患者临床治愈，同时布鲁氏菌滴度也显著改善。
