Moskalyk R E, Malicky J L
J Pharm Sci. 1975 Feb;64(2):292-4. doi: 10.1002/jps.2600640221.
The fusion of certain sulfanilamides with benzhydrol in the presence of anhydrous zinc chloride affords several different products, depending primarily on the temperature at which the reaction is carried out. With sulfanilamide itself, three different products were isolated at 100, 160, and 180 degrees. A sequence of steps is suggested to account for the three products, one of which involves an intramolecular rearrangement of a benzhydryl moiety. The fusion of benzhydrol with p-toludine gives 2,6-dibenzhydrylaniline and not the N,N-dibenzhydryl derivative as previously reported.
在无水氯化锌存在下，某些磺胺与二苯甲醇融合会生成几种不同的产物，这主要取决于反应进行时的温度。对于磺胺本身，在100℃、160℃和180℃下分离出了三种不同的产物。有人提出了一系列步骤来解释这三种产物，其中之一涉及二苯甲基部分的分子内重排。二苯甲醇与对甲苯胺融合生成2,6 - 二苯甲基苯胺，而不是先前报道的N,N - 二苯甲基衍生物。
