功能定义的突触小泡群体的形态学关联
Morphological correlates of functionally defined synaptic vesicle populations.
作者信息
Schikorski T, Stevens C F
机构信息
Howard Hughes Medical Institute and Molecular Neurobiology Lab, The Salk Institute, 10010 N. Torrey Pines Road, La Jolla, California 92037, USA.
出版信息
Nat Neurosci. 2001 Apr;4(4):391-5. doi: 10.1038/86042.
DOI:10.1038/86042
PMID:11276229
Abstract
By combining photoconversion of FM1-43-stained vesicles and electron microscopy of hippocampal synapses, we find evidence that the population of morphologically docked synaptic vesicles corresponds to the release-ready neurotransmitter quanta. Furthermore, those synaptic vesicles that are participating in cycles of exo- and endocytosis tend to be closer to the active zone than vesicles that are being held in reserve.
摘要
通过结合FM1-43染色囊泡的光转化和海马突触的电子显微镜观察，我们发现有证据表明，形态上对接的突触囊泡群体对应于随时可释放的神经递质量子。此外，那些参与胞吐和胞吞循环的突触囊泡往往比储备中的囊泡更靠近活性区。
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