Michurina S V, Kolesnikov S I, Alisievich S V, Yushchenko I Y
Institute of Clinical and Experimental Lymphology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk.
Bull Exp Biol Med. 2000 Dec;130(12):1209-11.
Reorganization of sinusoidal cells (endotheliocytes, Kupffer cells, and Ito cells) in the liver microregion of male rat liver exposed to 3,4-benzopyrene was studied. Synchronous activation of the lysosome-vacuole systems in Kupffer cells and endotheliocyte indicates cooperation of these cells in detoxification of benzopyrene and its metabolites. Ito cells lose lipid inclusions and actively proliferate; the appearance of intermediate forms between lipocytes and fibroblasts attests to activation of fibrogenesis in the liver.
研究了暴露于3,4-苯并芘的雄性大鼠肝脏微区域中肝血窦细胞（内皮细胞、库普弗细胞和贮脂细胞）的重组情况。库普弗细胞和内皮细胞中溶酶体-液泡系统的同步激活表明这些细胞在苯并芘及其代谢产物的解毒过程中存在协作。贮脂细胞失去脂滴并积极增殖；脂肪细胞和成纤维细胞之间中间形式的出现证明肝脏中纤维生成被激活。
