Pour P, Krüger F W, Althoff J, Cardesa A, Mohr U
J Natl Cancer Inst. 1975 Jan;54(1):141-6. doi: 10.1093/jnci/54.1.141.
2, 2-Dihydroxy-di-n-propylnitrosamine (DHPN), an assumed metabolite of di-n-propylnitrosamine (DPN), injected subcutaneously once weekly for life, was carcinogenic in Syrian hamsters. The main target organs were the respiratory tract, pancreas, liver, and kidneys. In the respiratory system the most affected segments were the nasal cavities and the lungs. Adenomas and adenocarcinomas, mostly of ductal origin, were induced in the pancreas. Liver neoplasms were hemangloendotheliomas, angiosarcomas, hepatocellular adenomas, cholangiomas, and cholangiocarcinomas. Kidney neoplasms were adenomas and adenocarcinomas. The morphology of the induced neoplasms was described, as well as the effects of DHPN, compared to those another possible metabolite of DPN, 2-hydroxypropyl-n-propylnitrosamine (2-HPPN), which is formed in vivo with only 1 aliphatic chain degraded via theta-oxidation.
2,2 - 二羟基 - 二正丙基亚硝胺（DHPN）是二正丙基亚硝胺（DPN）的一种假定代谢产物，每周皮下注射一次，终生给药，对叙利亚仓鼠具有致癌性。主要靶器官为呼吸道、胰腺、肝脏和肾脏。在呼吸系统中，受影响最严重的部位是鼻腔和肺部。胰腺中诱发了腺瘤和腺癌，大多起源于导管。肝脏肿瘤为血管内皮瘤、血管肉瘤、肝细胞腺瘤、胆管瘤和胆管癌。肾脏肿瘤为腺瘤和腺癌。描述了诱发肿瘤的形态，以及与DPN的另一种可能代谢产物2 - 羟丙基 - 正丙基亚硝胺（2 - HPPN）相比，DHPN的作用，2 - HPPN是在体内仅通过θ - 氧化降解一条脂肪链而形成的。
