Bilgen O, Atici T, Durak K, Bilgen M S
Department of Orthopaedics and Traumatology, Uludağ University, Bursa, Turkey.
J Int Med Res. 2001 Jan-Feb;29(1):7-12. doi: 10.1177/147323000102900102.
We studied the changes in serum C-reactive protein levels (CRP) and erythrocyte sedimentation rates (ESR) in patients with primary osteoarthritis, who underwent uncomplicated arthroplasty. Of the 28 patients studied, 12 had cementless total hip replacement (THR), and 16 underwent cemented total knee replacement (TKR) with a tourniquet. In both groups serum CRP levels increased rapidly after surgery, peaking on day 2 (THR 23.17 mg/dl, TKR 26.02 mg/dl), and dropping gradually to pre-operative values on day 21 in THR patients and at the end of the second month in TKR patients. ESR peaked on day 5 after operation (THR 100.5 mm/h, TKR 101.3 mm/h), dropping close to pre-operative values at the end of the third month in THR patients and at the end of the ninth month in TKR patients, although, even after a year, ESRs were slightly above their pre-operative values. Serum CRP levels changed more rapidly than ESRs and returned to normal more rapidly. CRP and ESR values tended to be higher in TKR than in THR patients.
我们研究了接受非复杂性关节置换术的原发性骨关节炎患者血清C反应蛋白水平（CRP）和红细胞沉降率（ESR）的变化。在研究的28例患者中，12例行非骨水泥型全髋关节置换术（THR），16例行骨水泥型全膝关节置换术（TKR）并使用止血带。两组患者术后血清CRP水平均迅速升高，在术后第2天达到峰值（THR组为23.17mg/dl，TKR组为26.02mg/dl），THR患者在术后第21天逐渐降至术前值，TKR患者在术后第二个月末降至术前值。ESR在术后第5天达到峰值（THR组为100.5mm/h，TKR组为101.3mm/h），THR患者在术后第三个月末、TKR患者在术后第九个月末降至接近术前值，不过即使在术后一年，ESR仍略高于术前值。血清CRP水平变化比ESR更快，且恢复正常也更快。TKR患者的CRP和ESR值往往高于THR患者。
