Parker L A, Kemp S W
Department of Psychology, Wilfrid Lauier University, Waterloo, Ontario, Canada.
Neuroreport. 2001 Mar 26;12(4):749-51. doi: 10.1097/00001756-200103260-00027.
Little is understood about effective countermeasures to the expression of anticipatory nausea and vomiting (ANV) in chemotherapy patients. We present a model of ANV based on the emetic reactions of the Suncus murinus (musk shrew). Following two pairings of a novel distinctive contextual cue with the emetic effects of an injection of lithium chloride, the context acquired the potential to elicit retching in the absence of the toxin. The expression of this conditioned retching reaction was completely suppressed by pretreatment with THC at a dose that did not suppress general activity. This provides the first experimental evidence in support of anecdotal reports that THC suppresses ANV.
关于化疗患者预期性恶心和呕吐（ANV）表达的有效对策了解甚少。我们基于臭鼩（麝鼩）的催吐反应提出了一种ANV模型。在将一种新颖独特的情境线索与注射氯化锂的催吐作用进行两次配对后，该情境在没有毒素的情况下获得了引发干呕的可能性。这种条件性干呕反应的表达在不抑制一般活动的剂量下用四氢大麻酚预处理后被完全抑制。这为支持四氢大麻酚抑制ANV的传闻报道提供了首个实验证据。
