University of Rochester Medical Center, Behavioral Medicine Unit, 265 Crittenden Blvd, Box 420658, Rochester, NY 14642, United States.
University of Rochester Medical Center, Behavioral Medicine Unit, 265 Crittenden Blvd, Box 420658, Rochester, NY 14642, United States.
Eur J Pharmacol. 2014 Jan 5;722:172-9. doi: 10.1016/j.ejphar.2013.09.071. Epub 2013 Oct 21.
As a specific variation of chemotherapy-induced nausea and vomiting, anticipatory nausea and vomiting (ANV) appears particularly linked to psychological processes. The three predominant factors related to ANV are classical conditioning; demographic and treatment-related factors; and anxiety or negative expectancies. Laboratory models have provided some support for these underlying mechanisms for ANV. ANV may be treated with medical or pharmacological interventions, including benzodiazepines and other psychotropic medications. However, behavioral treatments, including systematic desensitization, remain first line options for addressing ANV. Some complementary treatment approaches have shown promise in reducing ANV symptoms. Additional research into these approaches is needed. This review will address the underlying models of ANV and provide a discussion of these various treatment options.
作为化疗引起的恶心和呕吐的一种特殊变异，预期性恶心和呕吐（ANV）似乎与心理过程特别相关。与 ANV 相关的三个主要因素是经典条件作用、人口统计学和治疗相关因素以及焦虑或负面预期。实验室模型为 ANV 的这些潜在机制提供了一些支持。可以使用医学或药理学干预措施治疗 ANV，包括苯二氮䓬类药物和其他精神药物。然而，行为治疗，包括系统脱敏，仍然是治疗 ANV 的首选方法。一些补充治疗方法在减轻 ANV 症状方面显示出了希望。需要对这些方法进行更多的研究。这篇综述将讨论 ANV 的潜在模型，并讨论这些不同的治疗选择。
