Appel M J, Kuper C F, Woutersen R A
Department of General Toxicology, TNO Nutrition and Food Research, PO Box 360, 3700, AJ Zeist, The Netherlands.
Food Chem Toxicol. 2001 Mar;39(3):261-9. doi: 10.1016/s0278-6915(00)00137-x.
A study was performed to provide data on the disposition, accumulation and toxicity of sodium iron EDTA in comparison with iron (II) sulfate in rats on administration via the diet for 31 and 61 days. Clinical signs, body weights, food consumption, food conversion efficiency, hematology, clinical chemistry and pathology of selected organs were used as criteria for disclosing possible harmful effects. Determination of iron and total iron binding capacity in blood plasma and non-heme iron analysis in liver, spleen and kidneys were used to assess the disposition and accumulation of iron originating from sodium iron EDTA or iron (II) sulfate. It was concluded that, under the conditions of the present study, iron is accumulated from the diet in liver, spleen and kidneys in a dose-dependent manner, and iron derived from FeEDTA is taken up and/or accumulated less efficiently in liver and spleen than iron from FeSO(4). Moreover, feeding iron up to 11.5 and 11.2 mg/kg body weight/day, derived from FeSO(4) and FeEDTA, respectively, did not result in tissue iron excess nor in any other toxicologically significant effects.
进行了一项研究，以提供乙二胺四乙酸铁钠与硫酸亚铁（II）相比，在大鼠经饮食给药31天和61天时的处置、蓄积和毒性数据。将临床体征、体重、食物摄入量、食物转化效率、血液学、临床化学以及选定器官的病理学作为揭示可能有害影响的标准。通过测定血浆中的铁和总铁结合能力以及肝脏、脾脏和肾脏中的非血红素铁分析，来评估源自乙二胺四乙酸铁钠或硫酸亚铁（II）的铁的处置和蓄积情况。得出的结论是，在本研究条件下，饮食中的铁以剂量依赖的方式在肝脏、脾脏和肾脏中蓄积，并且与硫酸亚铁中的铁相比，乙二胺四乙酸铁中的铁在肝脏和脾脏中的摄取和/或蓄积效率较低。此外，分别喂食源自硫酸亚铁和乙二胺四乙酸铁的高达11.5和11.2毫克/千克体重/天的铁，不会导致组织铁过量，也不会产生任何其他毒理学上显著的影响。
