羰基铁粉对缺铁性贫血及其亚慢性毒性的影响。
Effects of carbonyl iron powder on iron deficiency anemia and its subchronic toxicity.
机构信息
State Key Laboratory of Bioreactor Engineering, Department of Food Science and Technology, School of Biotechnology, East China University of Science and Technology, Shanghai 200237, China.
Department of Radiotherapy of Zhongshan Hospital, Fudan University, Shanghai 200032, China.
出版信息
J Food Drug Anal. 2016 Oct;24(4):746-753. doi: 10.1016/j.jfda.2016.04.003. Epub 2016 Jun 2.
Carbonyl iron powder (CIP) has been used as a food additive or mineral supplement. However, the effects of CIP on iron deficiency anemia (IDA) and its subchronic toxicity have not been investigated. We found that oral administration of CIP at a dose of 2.96 mg/kg recovered the hemoglobin concentration of erythrocytes of IDA rats to the normal level after 8 days. The no observed adverse effect level of CIP in rats was considered to be > 200 mg/kg. The hematological and serum biochemical parameters of the rats did not differ significantly between the control and treated groups. There were no morphological changes observed in the organs including liver, kidneys, spleen, testes, stomach and intestine. Therefore, CIP might be a safe iron supplement.
羰基铁粉（CIP）已被用作食品添加剂或矿物质补充剂。然而，CIP 对缺铁性贫血（IDA）的影响及其亚慢性毒性尚未得到研究。我们发现，CIP 的口服剂量为 2.96mg/kg，可在 8 天后将 IDA 大鼠红细胞的血红蛋白浓度恢复到正常水平。CIP 在大鼠中的无观察到不良影响水平被认为大于 200mg/kg。对照组和处理组大鼠的血液学和血清生化参数没有显著差异。肝脏、肾脏、脾脏、睾丸、胃和肠道等器官均未观察到形态变化。因此，CIP 可能是一种安全的铁补充剂。
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