Dunselman G A, Groothuis P G, de Goeij A F, Evers J L
Research Institute Growth and Development (GROW), Maastricht University, Maastricht, The Netherlands.
Hum Reprod. 2001 Apr;16(4):605-7. doi: 10.1093/humrep/16.4.605.
Sampson's transplantation theory for the pathogenesis of peritoneal endometriosis is widely accepted. The events that take place, however, on the cellular and subcellular level during the transition of endometrial tissue in the abdominal cavity into peritoneal endometriosis remain controversial. The mesothelium plays a central role in the debate on this subject. The interaction between endometrium and peritoneum has been studied in an in-vitro model using amnion, peritoneum and mesothelial cells in culture on the one hand and cyclic and menstrual endometrium on the other hand. The results of these studies indicate that (i) an intact mesothelial lining prevents adhesion of shed endometrial tissue, (ii) shed endometrial tissue adheres to the peritoneal extracellular matrix and (iii) menstrual effluent creates its own adhesion sites by damaging the mesothelial lining thus exposing the extracellular matrix. Therefore we conclude that the mesothelium has the properties of Teflon, while the extracellular matrix resembles Velcro.
桑普森关于腹膜子宫内膜异位症发病机制的移植理论已被广泛接受。然而，在腹腔内的子宫内膜组织转变为腹膜子宫内膜异位症的过程中，细胞和亚细胞水平上发生的事件仍存在争议。间皮在关于这个问题的争论中起着核心作用。一方面，利用培养的羊膜、腹膜和间皮细胞，另一方面利用周期性和月经期的子宫内膜，在体外模型中研究了子宫内膜与腹膜之间的相互作用。这些研究结果表明：（i）完整的间皮衬里可防止脱落的子宫内膜组织粘连；（ii）脱落的子宫内膜组织粘附于腹膜细胞外基质；（iii）月经流出物通过破坏间皮衬里从而暴露细胞外基质来形成自身的粘连部位。因此，我们得出结论，间皮具有聚四氟乙烯的特性，而细胞外基质则类似于维可牢尼龙搭扣。
